Kozmai Anton, Poroznyy Mikhail, Gil Violetta, Butylskii Dmitrii, Lopatin Dmitry, Rodichenko Aleksey, Voroshilov Igor, Mareev Artem, Nikonenko Victor
Membrane Institute, Kuban State University, 149, Stavropolskaya Str., 350040 Krasnodar, Russia.
LLC "NSK", 353204 Dinskaya, Russia.
Polymers (Basel). 2024 Dec 14;16(24):3491. doi: 10.3390/polym16243491.
The relevance of the hemodialysis procedure is increasing worldwide due to the growing number of patients suffering from chronic kidney disease. Taking into account the structure of dialysis polymer membranes is an important aspect in their development to achieve the required performance of hemodialyzers. We propose a new mathematical model of mass transfer that allows hollow-fiber membrane structural parameters to be taken into account in simulating the clearance () of hemodialyzers in a way that does not require difficult to achieve close approximation to the exact geometry of the membrane porous structure. The model was verified by a comparison of calculations with experimental data on CL obtained using a lab-made dialyzer as well as commercially available ones. The simulations by the model show the non-trivial behavior of the dialyzer clearance as a function of membrane porosity (fp) and the arrangement of pores (α). The analysis of this behavior allows one to consider two strategies for increasing the CL of the dialyzer by optimizing the polymer membrane structure: (1) creating a membrane with a well-structured pore system (where α → 1) since doubling α at a high enough fp can lead to an almost tenfold increase in CL; (2) increasing the porosity of the membrane characterized by a random arrangement of pores (α → 0), where, at a relatively low α, a sharp increase in CL is observed with a small increase in fp over a certain threshold value.
由于慢性肾病患者数量不断增加，血液透析程序在全球范围内的相关性日益提高。在透析聚合物膜的开发过程中，考虑其结构是实现血液透析器所需性能的一个重要方面。我们提出了一种新的传质数学模型，该模型在模拟血液透析器的清除率（CL）时能够考虑中空纤维膜的结构参数，且无需对膜多孔结构的精确几何形状进行难以实现的近似。通过将计算结果与使用实验室自制透析器以及市售透析器获得的CL实验数据进行比较，对该模型进行了验证。该模型的模拟结果显示了透析器清除率随膜孔隙率（fp）和孔排列（α）的非平凡行为。对这种行为的分析使人们能够考虑通过优化聚合物膜结构来提高透析器CL的两种策略：（1）创建具有结构良好的孔系统的膜（α→1），因为在足够高的fp下将α加倍可导致CL几乎增加十倍；（2）增加具有随机孔排列特征的膜的孔隙率（α→0），在相对较低的α下，当fp超过某个阈值有小幅度增加时，CL会急剧增加。
