Miyasaka Takehiro, Sakai Kiyotaka
Department of Human Environmental Science, Shonan Institute of Technology, 1-1-25 Tsujido-nishi-kaigan, Fujisawa, Kanagawa, 251-8511, Japan.
Professor Emeritus of Waseda University, Tokyo, Japan.
J Artif Organs. 2023 Mar;26(1):1-11. doi: 10.1007/s10047-022-01359-8. Epub 2022 Sep 10.
Hemodialysis is a blood purification method based on solute removal by diffusion and incorporates filtration to improve the efficiency of water removal and removal of high molecular weight substances. It is now a well-established treatment, due to the improved performance of dialyzers. This review outlines the development process of dialyzers, focusing on the application based on the mathematical analysis. First, phenomena occurring in the vicinity of the dialysis membrane are explained using a film model for diffusion and a gel polarization model for filtration. Then, currently established dialyzer designs are introduced using mathematical analysis. Furthermore, the design of dialyzers to promote internal filtration, the designs of hemodiafilters suitable for online hemodiafiltration (HDF), and the design of compact dialyzer for are also presented.
血液透析是一种基于溶质扩散清除的血液净化方法，并结合过滤以提高水分清除效率和高分子量物质的清除率。由于透析器性能的改善，它现在已成为一种成熟的治疗方法。本综述概述了透析器的发展过程，重点是基于数学分析的应用。首先，使用扩散的膜模型和过滤的凝胶极化模型来解释透析膜附近发生的现象。然后，通过数学分析介绍当前已确立的透析器设计。此外，还介绍了促进内部过滤的透析器设计、适用于在线血液透析滤过（HDF）的血液透析滤过器设计以及紧凑型透析器的设计。
