Koepke J W, Staudenmayer H, Selner J C
Ann Allergy. 1985 Mar;54(3):213-5.
Sensitivity to an inhaled sulfite-containing solution was evaluated in 13 asthmatics and ten nonasthmatic controls. Three of the 13 asthma patients were known to be sensitive to ingested sulfite and ten were not sensitive. All three sulfite-sensitive patients developed bronchospasm following sulfite inhalation challenges. Four of the ten asthmatics not sensitive to ingested sulfite developed bronchospasm following sulfite inhalation. The control subjects showed no reaction to inhaled sulfite. This study demonstrated that all asthmatics sensitive to ingested sulfite developed bronchoconstriction with inhaled sulfite. Furthermore, sensitivity to inhaled sulfite was more common than sensitivity to ingested sulfite in asthmatic patients. Possible reasons for this difference are discussed.
对13名哮喘患者和10名非哮喘对照者进行了吸入含亚硫酸盐溶液的敏感性评估。13名哮喘患者中有3名已知对摄入的亚硫酸盐敏感，10名不敏感。所有3名对亚硫酸盐敏感的患者在亚硫酸盐吸入激发试验后均出现支气管痉挛。10名对摄入亚硫酸盐不敏感的哮喘患者中有4名在亚硫酸盐吸入后出现支气管痉挛。对照受试者对吸入亚硫酸盐无反应。这项研究表明，所有对摄入亚硫酸盐敏感的哮喘患者吸入亚硫酸盐后均出现支气管收缩。此外，在哮喘患者中，对吸入亚硫酸盐的敏感性比对摄入亚硫酸盐的敏感性更常见。文中讨论了造成这种差异的可能原因。
