Welch Cooper, Khawar Mobaris, Böhm Benjamin, Gryczke Andreas, Ries Florian
Technical University of Darmstadt, Department of Mechanical Engineering, Reactive Flows and Diagnostics, Otto-Berndt-Str. 3, 64287 Darmstadt, Germany.
AbbVie Deutschland GmbH & Co. KG, Knollstraße, 67061 Ludwigshafen am Rhein, Germany.
Pharmaceutics. 2024 Dec 2;16(12):1547. doi: 10.3390/pharmaceutics16121547.
Atomization plays a key role in spray drying, a process widely used in the pharmaceutical, chemical, biological, and food and beverage industries. In the pharmaceutical industry, spray drying is particularly important in the preparation of amorphous solid dispersions, which enhance the bioavailability of active pharmaceutical ingredients when mixed with a polymer. In this study, a 3D-printed adaptation of a commercial spray dryer nozzle (PHARMA-SD PSD-1, GEA Group AG) was used to investigate the atomization of PVP-VA 64 polymer solutions under varying flow conditions using high-speed diffuse back-illumination. Unlike pure water, the atomization process of the polymer solution was governed by viscous effects rather than surface tension, as indicated by stringing effects in the liquid core and the formation of larger droplets. In addition, the classical Ohnesorge diagram accurately predicted the atomization regime with increasing Reynolds numbers and could be modified to reasonably predict the breakup regime by considering the transitions between regime boundaries. The use of such a modified diagram facilitates the efficient selection of viscous fluid solutions and process parameters to achieve complete spray formation.
雾化在喷雾干燥中起着关键作用，喷雾干燥是制药、化工、生物以及食品和饮料行业广泛使用的一种工艺。在制药行业，喷雾干燥在无定形固体分散体的制备中尤为重要，当与聚合物混合时，无定形固体分散体可提高活性药物成分的生物利用度。在本研究中，使用了一种商用喷雾干燥器喷嘴（PHARMA-SD PSD-1，GEA集团股份公司）的3D打印适配装置，通过高速漫反射背照光来研究不同流动条件下聚乙烯吡咯烷酮-醋酸乙烯酯64（PVP-VA 64）聚合物溶液的雾化情况。与纯水不同，聚合物溶液的雾化过程受粘性效应而非表面张力控制，这表现为液芯中的拉丝效应以及形成更大的液滴。此外，经典的奥内佐格图能随着雷诺数的增加准确预测雾化区域，并且通过考虑区域边界之间的转变，可以对其进行修正以合理预测破碎区域。使用这种修正后的图表有助于高效选择粘性流体溶液和工艺参数，以实现完整的喷雾形成。
