Geggel H S, Friend J, Boruchoff S A
Ann Ophthalmol. 1985 Jan;17(1):27-31.
Corneal epithelial dysplasia is a rare clinical problem. It is not known whether the corneal epithelial cells undergo dysplastic changes in situ or in the region of the limbal or conjunctival epithelium with subsequent centripetal migration onto the cornea. We obtained an intact, dysplastic corneal epithelial sheet and samples of conjunctival tissue from a 75-year-old patient. Light and transmission electron microscopic examination of the dysplastic corneal epithelium showed histologic evidence of conjunctival, limbal, and corneal epithelium. The adjacent conjunctiva appeared normal except for a possible slight decrease in goblet cells. The 3H-thymidine uptake indicated a normal mitotic index for the conjunctiva. Glycogen content of the dysplastic sheet showed high values seen with corneal and not conjunctival epithelium. The dysplasia recurred despite wide conjunctival resection. Although no final conclusions can be made, we feel our studies support the hypothesis that the dysplastic process in our patient arose de novo in the corneal epithelium.
角膜上皮发育异常是一种罕见的临床问题。目前尚不清楚角膜上皮细胞是在原位发生发育异常变化，还是在角膜缘或结膜上皮区域发生变化，随后向心性迁移到角膜上。我们从一名75岁患者身上获取了完整的发育异常角膜上皮片和结膜组织样本。对发育异常的角膜上皮进行光镜和透射电镜检查，发现有结膜、角膜缘和角膜上皮的组织学证据。相邻结膜除杯状细胞可能略有减少外，外观正常。3H-胸腺嘧啶核苷摄取显示结膜有正常的有丝分裂指数。发育异常片的糖原含量显示出角膜上皮而非结膜上皮所见的高值。尽管进行了广泛的结膜切除术，发育异常仍复发。虽然无法得出最终结论，但我们认为我们的研究支持这样一种假设，即我们患者的发育异常过程是在角膜上皮中从头发生的。
