Experimental intravitreal 5-fluorocytosine.

The pyrimidine 5-fluorocytosine is a water soluble agent which may be suitable for intravitreal injection in the treatment of Candida endophthalmitis. Experimental ocular toxicity studies of intravitreal 5-fluorocytosine have been performed in rabbits with the aid of slit-lamp biomicroscopy, indirect ophthalmoscopy, electroretinography, and histologic examination. Intravitreal injection of 100 micrograms 5-fluorocytosine produced no detectable ocular injury.