Tripathi Devika, Gupta Tanya, Rai Awani Kumar, Pandey Prashant
Department of Pharmacy, PSIT-Pranveer Singh Institute of Technology (Pharmacy), Kanpur, 208002, Uttar Pradesh, India.
Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow, 226025, U.P., India.
Anticancer Agents Med Chem. 2025;25(7):468-489. doi: 10.2174/0118715206348821241119100134.
Oral cancer, currently ranked 16th among the most prevalent malignancies worldwide according to GLOBOCAN, presents significant challenges to global oral health. Conventional treatment modalities such as surgery, radiation, and chemotherapy often have limitations, prompting the need for innovative therapeutic approaches. Tissue engineering has emerged as a promising solution aimed at developing biocompatible, functional, and biologically responsive tissue constructs. This approach involves the integration of cells, bioactive compounds, and scaffolds to enhance treatment efficacy. Electrospun nanofibers, mimicking the extracellular matrix, exhibit considerable potential in addressing complex oral health issues by influencing cellular behavior. The versatility of electrospinning technology allows for the fabrication of fiber scaffolds with high surface area, making them ideal for localized delivery of bioactive compounds or pharmaceuticals. Enhancing these electrospun scaffolds with growth factors, nanoparticles, and biologically active substances significantly increases their therapeutic appeal in oral cancer management. This review offers a comprehensive examination of the various applications of electrospun nanofibers in oral cancer therapy. Utilizing electronic databases such as PubMed, CrossREF, and Google Scholar, we conducted an extensive review of relevant literature concerning "electrospun nanofibers" and their therapeutic potential in oral cancer treatment. Key topics addressed include engineering methodologies, drug diffusion mechanisms, factors influencing nanofiber scaffold design, toxicity concerns, and clinical implications. The findings underscore the transformative potential of electrospun nanofibers in revolutionizing oral cancer therapy.
根据全球癌症负担数据（GLOBOCAN），口腔癌目前在全球最常见的恶性肿瘤中排名第16位，给全球口腔健康带来了重大挑战。手术、放疗和化疗等传统治疗方式往往存在局限性，这促使人们需要创新的治疗方法。组织工程作为一种有前景的解决方案应运而生，旨在开发具有生物相容性、功能性和生物反应性的组织构建体。这种方法涉及细胞、生物活性化合物和支架的整合，以提高治疗效果。电纺纳米纤维模仿细胞外基质，通过影响细胞行为，在解决复杂的口腔健康问题方面具有巨大潜力。电纺技术的多功能性使得能够制造具有高表面积的纤维支架，使其成为生物活性化合物或药物局部递送的理想选择。用生长因子、纳米颗粒和生物活性物质增强这些电纺支架，显著提高了它们在口腔癌治疗中的治疗吸引力。本综述全面考察了电纺纳米纤维在口腔癌治疗中的各种应用。我们利用PubMed、CrossREF和谷歌学术等电子数据库，对有关“电纺纳米纤维”及其在口腔癌治疗中的治疗潜力的相关文献进行了广泛综述。涉及的关键主题包括工程方法、药物扩散机制、影响纳米纤维支架设计的因素、毒性问题和临床意义。研究结果强调了电纺纳米纤维在彻底改变口腔癌治疗方面的变革潜力。
