Department of Biomaterials Engineering, Kangwon National University, Chuncheon, Republic of Korea.
Adv Drug Deliv Rev. 2009 Oct 5;61(12):1033-42. doi: 10.1016/j.addr.2009.07.007. Epub 2009 Jul 27.
Electrospun nanofibers with a high surface area to volume ratio have received much attention because of their potential applications for biomedical devices, tissue engineering scaffolds, and drug delivery carriers. In order to develop electrospun nanofibers as useful nanobiomaterials, surfaces of electrospun nanofibers have been chemically functionalized for achieving sustained delivery through physical adsorption of diverse bioactive molecules. Surface modification of nanofibers includes plasma treatment, wet chemical method, surface graft polymerization, and co-electrospinning of surface active agents and polymers. A variety of bioactive molecules including anti-cancer drugs, enzymes, cytokines, and polysaccharides were entrapped within the interior or physically immobilized on the surface for controlled drug delivery. Surfaces of electrospun nanofibers were also chemically modified with immobilizing cell specific bioactive ligands to enhance cell adhesion, proliferation, and differentiation by mimicking morphology and biological functions of extracellular matrix. This review summarizes surface modification strategies of electrospun polymeric nanofibers for controlled drug delivery and tissue engineering.
具有高表面积与体积比的静电纺纳米纤维因其在生物医学装置、组织工程支架和药物输送载体方面的潜在应用而受到广泛关注。为了将静电纺纳米纤维开发为有用的纳米生物材料，静电纺纳米纤维的表面已通过物理吸附各种生物活性分子进行化学功能化，以实现持续的药物输送。纳米纤维的表面修饰包括等离子体处理、湿法化学方法、表面接枝聚合以及表面活性剂和聚合物的共静电纺丝。各种生物活性分子，包括抗癌药物、酶、细胞因子和多糖，被包裹在内部或物理固定在表面上，以实现药物的控制释放。静电纺纳米纤维的表面也通过固定细胞特异性生物活性配体进行化学修饰，通过模拟细胞外基质的形态和生物学功能来增强细胞黏附、增殖和分化。本综述总结了用于控制药物输送和组织工程的静电纺丝聚合物纳米纤维的表面修饰策略。
