Chen Shu-Zi-Qi, Pan Rou-Jun, Sun Meng-Yan, He Lian-Ping, Li Cui-Ping
School of Medicine, Taizhou University, No.1139, Shifu Avenue, Jiaojiang, 318000, Zhejiang, China.
J Health Popul Nutr. 2025 Jan 7;44(1):5. doi: 10.1186/s41043-024-00720-2.
Iron overload increases fasting blood glucose level in mice, leading to insulin insensitivity. However, no such relationship has been shown in the population. The relationship between whole blood iron levels and fasting blood glucose levels remained unclear. This study aimed to determine whether whole blood iron levels were associated with fasting blood glucose levels in community-dwelling older adults. This cross-sectional study was based on a community population and analyzed the distribution of whole blood iron and fasting blood glucose in a community population. A sample of 1560 community residents had their fasting blood glucose, gender, and age measured during the study. Covariates were assessed using correlation analysis, partial correlation analysis, and Student's t-test. To further investigate the impact of confounding factors in this study, we compared variations in whole blood iron levels between genders. Pearson correlation analysis showed no correlation between whole blood iron and fasting blood glucose. After adjusting for age and gender, no correlation was found between whole blood iron and fasting blood glucose as well. However, Pearson correlation analysis showed a correlation between whole blood iron and age(P<0.05, r=-0.181). whole blood iron concentrations gradually decreased with age. At the same time, mean whole blood iron concentrations were lower 420 mg/l among women and men in the community. And the mean levels of whole blood iron were higher in men(504.08 mg/l ± 45.98 mg/l) than in women(453.80 mg/l ± 38.13 mg/l). Our study indicated no association between whole blood iron. Age was a covariate, but fasting blood glucose was not, and fasting blood glucose was independently associated with whole blood iron concentrations, suggesting that older women in this community need adequate iron supplementation.
铁过载会升高小鼠的空腹血糖水平，导致胰岛素抵抗。然而，在人群中尚未发现这种关系。全血铁水平与空腹血糖水平之间的关系仍不明确。本研究旨在确定社区居住的老年人全血铁水平与空腹血糖水平是否相关。这项横断面研究基于社区人群，分析了社区人群中全血铁和空腹血糖的分布情况。在研究期间，对1560名社区居民样本进行了空腹血糖、性别和年龄测量。使用相关分析、偏相关分析和学生t检验评估协变量。为了进一步研究本研究中混杂因素的影响，我们比较了不同性别之间全血铁水平的差异。Pearson相关分析显示全血铁与空腹血糖之间无相关性。在调整年龄和性别后，全血铁与空腹血糖之间也未发现相关性。然而，Pearson相关分析显示全血铁与年龄之间存在相关性（P<0.05，r=-0.181）。全血铁浓度随年龄逐渐降低。同时，社区中女性和男性的全血铁平均浓度均低于420mg/l。男性的全血铁平均水平（504.08mg/l±45.98mg/l）高于女性（453.80mg/l±38.13mg/l）。我们的研究表明全血铁之间无关联。年龄是一个协变量，但空腹血糖不是，空腹血糖与全血铁浓度独立相关，这表明该社区的老年女性需要适当补充铁。
