Kushimoto H, Aoki T
Arch Dermatol. 1985 Mar;121(3):355-60.
Six patients had type I hypersensitivity to wheat. Three cases were exercise-induced anaphylaxis to wheat, one was exercise-induced urticarial reaction to wheat (with angioedema), and the remaining two were exercise-accentuated urticarial reaction to wheat. Elimination of wheat from the diet completely cleared these symptoms. Allergens were prepared from wheat, gluten, gliadin, and glutenin by simple extraction and enzyme digestion, and these preparations were used in skin tests. The allergens obtained from gluten, gliadin, and glutenin by pepsin digestion were qualitatively different from wheat and gluten allergens obtained by simple extraction and were more related to exercise-induced anaphylaxis. Trypsin digestion showed no such effect and abolished all these allergens. These results indicate that wheat allergens are reinforced in the stomach and destroyed in the jejunum.
6例患者对小麦有I型超敏反应。3例为运动诱发的小麦过敏反应，1例为运动诱发的小麦荨麻疹反应（伴有血管性水肿），其余2例为运动加重的小麦荨麻疹反应。饮食中去除小麦后这些症状完全消失。通过简单提取和酶消化从小麦、麸质、麦醇溶蛋白和麦谷蛋白中制备过敏原，并将这些制剂用于皮肤试验。经胃蛋白酶消化从麸质、麦醇溶蛋白和麦谷蛋白中获得的过敏原在质量上与通过简单提取获得的小麦和麸质过敏原不同，且与运动诱发的过敏反应更相关。胰蛋白酶消化未显示出这种效果，且消除了所有这些过敏原。这些结果表明小麦过敏原在胃中增强而在空肠中被破坏。
