Aoki T, Kushimoto H
N Engl Reg Allergy Proc. 1987 Jan-Feb;8(1):34-6. doi: 10.2500/108854187779045394.
Type I wheat ingestion allergy is a special type of food allergy because the patient usually is not aware of his allergy. The unawareness comes from two reasons; one is that the clinical symptom appears not immediately after ingestion of wheat products but occurs sometime (30-60 min) later, and the other is that it may not appear if the patient does not exercise at this particular time. Therefore, the reaction does not always follow wheat ingestion. The study of enzymatically digested gluten antigens in the patients disclosed that the allergenicity to wheat was reinforced by peptic digestion but abolished by further tryptic digestion, indicating that allergen activity was most potent in the stomach. Anaphylaxis may occur in some patients after wheat ingestion and exercise. Therefore, in exercise-induced anaphylaxis without apparent allergy, one should consider wheat allergy.
I型小麦摄入过敏是一种特殊类型的食物过敏，因为患者通常并未意识到自己过敏。这种未察觉有两个原因：一是临床症状并非在摄入小麦制品后立即出现，而是在一段时间（30 - 60分钟）后出现；另一个原因是，如果患者在这个特定时间没有运动，症状可能不会出现。因此，反应并不总是与摄入小麦相关。对患者体内酶消化的麸质抗原的研究表明，胃蛋白酶消化会增强对小麦的致敏性，但进一步的胰蛋白酶消化会消除这种致敏性，这表明过敏原活性在胃中最强。一些患者在摄入小麦并运动后可能会发生过敏反应。因此，在没有明显过敏的运动诱发过敏反应中，应考虑小麦过敏。
