Wan Xinliang, Mo Handan, Chen Jixin, Zhou Qichun, Qiu Shenghong, Zou Yongchun, Wu Wanyin, Tang Qing, Wang Sumei
The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Clinical and Basic Research Team of TCM Prevention and Treatment of NSCLC, Department of Oncology, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Chinese Medicine Guangdong Laboratory, Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
BMJ Open. 2025 Jan 7;15(1):e087181. doi: 10.1136/bmjopen-2024-087181.
To conduct an umbrella review to extensively evaluate and summarise the evidence regarding the relationship between risk factors and the occurrence of brain metastasis in lung cancer.
Umbrella review of systematic reviews and meta-analyses.
Four databases (PubMed, EMBASE, Web of Science and Cochrane Library) were searched from inception to 10 November 2024.
Systematic reviews and meta-analyses that assessed the relationship between risk factors and brain metastasis in lung cancer were included. Only English language studies were considered.
Two authors independently extracted data and assessed the methodological quality and risk of bias of the included studies. Certainty of evidence was evaluated and summarised for each identified risk factor.
Six systematic reviews/meta-analyses were included. The quality of these studies varied, with most having low or critically low methodological quality. Epidermal growth factor receptor mutations, female gender, lung adenocarcinoma and advanced tumour stage were associated with an increased risk of brain metastasis. Prophylactic cranial irradiation and older age were associated with reduced risk.
This umbrella review suggests that several risk factors may be associated with brain metastasis in lung cancer, but the overall quality of evidence is low. Future studies with improved methodologies are needed to validate these findings.
CRD42023484563.
进行一项伞状综述，以广泛评估和总结关于肺癌危险因素与脑转移发生之间关系的证据。
对系统评价和荟萃分析的伞状综述。
检索了四个数据库（PubMed、EMBASE、Web of Science和Cochrane图书馆），检索时间从建库至2024年11月10日。
纳入评估肺癌危险因素与脑转移之间关系的系统评价和荟萃分析。仅考虑英文研究。
两位作者独立提取数据，并评估纳入研究的方法学质量和偏倚风险。对每个确定的危险因素评估并总结证据的确定性。
纳入了六项系统评价/荟萃分析。这些研究的质量各不相同，大多数研究的方法学质量低或极低。表皮生长因子受体突变、女性、肺腺癌和肿瘤晚期与脑转移风险增加相关。预防性颅脑照射和老年与风险降低相关。
这项伞状综述表明，若干危险因素可能与肺癌脑转移相关，但证据的总体质量较低。需要采用改进方法的未来研究来验证这些发现。
PROSPERO注册号：CRD42023484563。
