ABO血型与脓毒症相关性血小板减少症的风险：一项单中心回顾性研究。
ABO Blood Group and Risk Associated With Sepsis-Associated Thrombocytopenia: A Single-Center Retrospective Study.
作者信息
Liufu Rong, Chen Yan, Wang Jing-Yi, Wang Yang-Yan-Qiu, Wu Yao, Jiang Wei, Wang Chun-Yao, Peng Jin-Min, Weng Li, Du Bin
机构信息
Medical ICU, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.
Department of Cardiovascular Intensive Care Unit, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
出版信息
Crit Care Med. 2025 Feb 1;53(2):e353-e361. doi: 10.1097/CCM.0000000000006523. Epub 2024 Nov 15.
OBJECTIVES
This study aimed to investigate the relationship between ABO blood group and sepsis-associated thrombocytopenia (SAT).
DESIGN AND SETTING
The primary outcome was SAT within the first 72 hours of ICU admission.
PATIENTS
The retrospective study included 9113 patients diagnosed with sepsis from January 2014 to December 2022. A total of 6296 patients eventually were included into the study, who were divided into four groups based on ABO blood group.
INTERVENTIONS
None.
MEASUREMENTS AND MAIN RESULTS
A total of 2494 patients (39.6%) were diagnosed with SAT, and 712 (11.3%) of them experiencing severe SAT. The occurrence of SAT among the ABO blood groups was significantly lower in AB blood group compared with the other groups ( p = 0.032). Individuals in AB blood group were less likely to experience severe SAT ( p = 0.028). In multivariate analysis, B blood group (odds ratio [OR], 1.32; 95% CI, 1.05-1.67) and O (OR, 1.37; 95% CI, 1.09-1.72) were significantly associated with a higher occurrence of SAT compared with AB blood group. In multivariate analyses, A blood group (OR, 1.68; 95% CI, 1.16-2.42), B blood group (OR, 1.74; 95% CI, 1.74-2.50), and O blood group (OR, 1.72; 95% CI, 1.20-2.48) remained significantly risk factors associated with a higher occurrence of severe SAT compared with AB blood group.
CONCLUSIONS
B blood group and O were associated with an increased risk of SAT and severe SAT.
目的
本研究旨在探讨ABO血型与脓毒症相关血小板减少症（SAT）之间的关系。
设计与背景
主要观察指标为入住重症监护病房（ICU）后72小时内发生的SAT。
患者
这项回顾性研究纳入了2014年1月至2022年12月期间诊断为脓毒症的9113例患者。最终共有6296例患者纳入研究，根据ABO血型分为四组。
干预措施
无。
测量指标与主要结果
共有2494例患者（39.6%）被诊断为SAT，其中712例（11.3%）发生严重SAT。AB血型组SAT的发生率显著低于其他组（p = 0.032）。AB血型组个体发生严重SAT的可能性较小（p = 0.028）。多因素分析显示，与AB血型组相比，B血型组（比值比[OR]，1.32；95%置信区间[CI]，1.05 - 1.67）和O血型组（OR，1.37；95% CI，1.09 - 1.72）发生SAT的几率显著更高。在多因素分析中，与AB血型组相比，A血型组（OR，1.68；95% CI，1.16 - 2.42）、B血型组（OR，1.74；95% CI，1.74 - 2.50）和O血型组（OR，1.72；95% CI，1.20 - 2.48）仍然是与严重SAT发生率较高相关的显著危险因素。
结论
B血型和O血型与SAT及严重SAT风险增加相关。
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