McMahon K E, Habeeb O, Bautista G M, Levin S, DeChristopher P J, Glynn L A, Jeske W, Muraskas J K
Loyola University Medical Center, Maywood, IL, USA.
New York University Langone Medical Center, New York, NY, USA.
J Neonatal Perinatal Med. 2019;12(1):81-86. doi: 10.3233/NPM-17115.
Numerous studies have examined the association between ABO blood groups and adult disease states, but very few have studied the neonatal population. The objective of this study was to determine the relationship between AB blood group and the occurrence of common neonatal disorders such as neutropenia at birth, sepsis, respiratory distress syndrome (RDS), intraventricular hemorrhage (IVH), retinopathy of prematurity (ROP), and patent ductus arteriosus (PDA) compared to all other blood groups.
We performed a retrospective review on 3,981 infants born at 22 0/7 to 42 6/7 weeks' gestational age and compared the relative risk of neonatal diseases in infants with AB blood group to that of infants with all other blood groups (A, B, and O).
When compared to all other blood groups, AB infants demonstrated an increased risk for developing negative clinical outcomes. AB blood group was significantly associated with a 14-89% increased risk of neutropenia at birth, sepsis, RDS, and ROP. Risks for IVH and PDA were not significant.
We hypothesize that the phenotypic expression of A and B antigens, rather than the antigens themselves, in the AB group may reveal an enhanced susceptibility to injury at the endothelial level resulting in an increased risk for disease development.
众多研究探讨了ABO血型与成人疾病状态之间的关联，但针对新生儿群体的研究却很少。本研究的目的是确定AB血型与出生时中性粒细胞减少、败血症、呼吸窘迫综合征（RDS）、脑室内出血（IVH）、早产儿视网膜病变（ROP）和动脉导管未闭（PDA）等常见新生儿疾病的发生之间的关系，并与所有其他血型进行比较。
我们对3981例孕龄在22 0/7至42 6/7周出生的婴儿进行了回顾性研究，并比较了AB血型婴儿与所有其他血型（A、B和O）婴儿患新生儿疾病的相对风险。
与所有其他血型相比，AB血型婴儿出现不良临床结局的风险增加。AB血型与出生时中性粒细胞减少、败血症、RDS和ROP的风险显著增加14%至89%相关。IVH和PDA的风险不显著。
我们推测，AB血型中A和B抗原的表型表达而非抗原本身，可能揭示出在内皮水平上对损伤的易感性增强，从而导致疾病发生风险增加。
