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HIV感染中不同寿命阶段的单核细胞：光明与阴影

Monocytes across life span in HIV infection: lights and shadows.

作者信息

Neri Alessia, Olivieri Giulio, Pighi Chiara, Amodio Donato, Cotugno Nicola, Palma Paolo

机构信息

Clinical and Research Unit of Clinical Immunology and Vaccinology, Bambino Gesù Children's Hospital, IRCCS.

PhD Program in Immunology, Molecular Medicine and Applied Biotechnology.

出版信息

Curr Opin HIV AIDS. 2025 Mar 1;20(2):133-144. doi: 10.1097/COH.0000000000000910. Epub 2025 Jan 8.

DOI:10.1097/COH.0000000000000910
PMID:39774439
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11809736/
Abstract

PURPOSE OF REVIEW

This review highlights the role of monocytes in the pathogenesis of HIV-1 infection, focusing on their involvement in the inflammatory response and their function as viral targets and long-term reservoirs.

RECENT FINDINGS

Monocytes have been categorized into three subsets: classical, intermediate, and nonclassical, each with distinct functional characteristics. Advances in genetic sequencing technologies have enabled a more in-depth exploration of the phenotypic and functional variations among these subsets, particularly in the context of HIV. These findings underscore their role as crucial components of the immune response and as reservoirs for the virus.

SUMMARY

Previous studies on the role of monocytes have demonstrated their contribution to persistent infection and chronic immune activation, especially in adults living with HIV. The lessons learned from these studies should now be harnessed to design studies focused on newborns and children with vertically acquired HIV.

摘要

综述目的

本综述重点介绍单核细胞在HIV-1感染发病机制中的作用，着重探讨其在炎症反应中的参与情况以及作为病毒靶标和长期储存库的功能。

最新发现

单核细胞已被分为三个亚群：经典型、中间型和非经典型，每个亚群都具有独特的功能特征。基因测序技术的进展使得能够更深入地探究这些亚群之间的表型和功能差异，特别是在HIV感染的背景下。这些发现强调了它们作为免疫反应关键组成部分和病毒储存库的作用。

总结

先前关于单核细胞作用的研究表明，它们对持续感染和慢性免疫激活有贡献，尤其是在感染HIV的成年人中。现在应该利用从这些研究中吸取的经验教训，设计针对垂直感染HIV的新生儿和儿童的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e77a/11809736/cdaa4375a8ed/cohiv-20-133-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e77a/11809736/a345f7c61e83/cohiv-20-133-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e77a/11809736/63f27996ddd8/cohiv-20-133-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e77a/11809736/0dab333f0612/cohiv-20-133-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e77a/11809736/cdaa4375a8ed/cohiv-20-133-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e77a/11809736/a345f7c61e83/cohiv-20-133-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e77a/11809736/63f27996ddd8/cohiv-20-133-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e77a/11809736/0dab333f0612/cohiv-20-133-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e77a/11809736/cdaa4375a8ed/cohiv-20-133-g004.jpg

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本文引用的文献

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Sci Rep. 2024 Oct 28;14(1):25792. doi: 10.1038/s41598-024-74066-4.
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HIV-1-DNA/RNA and immunometabolism in monocytes: contribution to the chronic immune activation and inflammation in people with HIV-1.HIV-1 病毒 DNA/RNA 与免疫代谢：在 HIV-1 感染者中对慢性免疫激活和炎症的贡献。
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Monocyte Single-Cell Multimodal Profiling in Cardiovascular Disease Risk States.
单核细胞单细胞多模态分析在心血管疾病风险状态中的应用。
Circ Res. 2024 Aug 30;135(6):685-700. doi: 10.1161/CIRCRESAHA.124.324457. Epub 2024 Aug 6.
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Monocyte to macrophage differentiation and changes in cellular redox homeostasis promote cell type-specific HIV latency reactivation.单核细胞向巨噬细胞分化以及细胞氧化还原稳态的改变促进了细胞类型特异性的 HIV 潜伏再激活。
Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2313823121. doi: 10.1073/pnas.2313823121. Epub 2024 Apr 29.
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Monocyte Differentiation and Heterogeneity: Inter-Subset and Interindividual Differences.单核细胞分化和异质性：亚群间和个体间差异。
Int J Mol Sci. 2023 May 15;24(10):8757. doi: 10.3390/ijms24108757.
6
Single-cell transcriptomic landscape identifies the expansion of peripheral blood monocytes as an indicator of HIV-1-TB co-infection.单细胞转录组图谱确定外周血单核细胞的扩增是HIV-1与结核杆菌合并感染的一个指标。
Cell Insight. 2022 Jan 21;1(1):100005. doi: 10.1016/j.cellin.2022.100005. eCollection 2022 Feb.
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