Shibata Shutaro, Noguchi-Shinohara Moeko, Shima Ayano, Ozaki Taro, Usui Yuta, Taki Yasuyuki, Uchida Kazuhiro, Honda Takanori, Hata Jun, Ohara Tomoyuki, Mikami Tatsuya, Maeda Tetsuya, Mimura Masaru, Nakashima Kenji, Iga Jun-Ichi, Takebayashi Minoru, Ninomiya Toshiharu, Ono Kenjiro
Department of Neurology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
Department of Aging Research and Geriatric Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
NPJ Sci Food. 2025 Jan 7;9(1):2. doi: 10.1038/s41538-024-00364-w.
This study investigated the association between green tea or coffee consumption with cerebral white matter lesions and hippocampal and total brain volumes among 8766 community-dwelling participants recruited from the Japan Prospective Studies Collaboration for Aging and Dementia between 2016 and 2018. A Food Frequency Questionnaire was used to assess green tea and coffee consumption, whereas brain magnetic resonance imaging was performed to assess cerebral white matter lesions, hippocampal volume, and total brain volume. Multivariable-adjusted analysis revealed significant correlations between fewer cerebral white matter lesions and higher green tea consumption, whereas no significant differences were found between green tea consumption and hippocampal or total brain volume. Regarding coffee consumption, no significant differences were observed in cerebral white matter lesions or hippocampal or total brain volumes. Hence, higher green tea consumption was associated with fewer cerebral white matter lesions, suggesting that it may be useful in preventing dementia.
本研究在2016年至2018年期间从日本老龄化与痴呆前瞻性研究合作项目招募的8766名社区居民参与者中，调查了绿茶或咖啡摄入量与脑白质病变、海马体及全脑体积之间的关联。使用食物频率问卷评估绿茶和咖啡的摄入量，同时进行脑磁共振成像以评估脑白质病变、海马体体积和全脑体积。多变量调整分析显示，脑白质病变较少与绿茶摄入量较高之间存在显著相关性，而绿茶摄入量与海马体或全脑体积之间未发现显著差异。关于咖啡摄入量，在脑白质病变、海马体或全脑体积方面未观察到显著差异。因此，较高的绿茶摄入量与较少的脑白质病变相关，这表明绿茶可能有助于预防痴呆。
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