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咖啡和茶的摄入与高血压人群痴呆风险的关联:一项前瞻性队列研究。

Association between coffee and tea consumption and the risk of dementia in individuals with hypertension: a prospective cohort study.

机构信息

School of Public Health, Ningxia Medical University, Yinchuan, 750004, China.

Key Laboratory of Environmental Factors and Chronic Disease Control, Ningxia Medical University , Yinchuan, 750004, China.

出版信息

Sci Rep. 2024 Sep 10;14(1):21063. doi: 10.1038/s41598-024-71426-y.

Abstract

Many studies have shown that drinking coffee and tea may be associated with the risk of hypertension and dementia. Limited research exists on their impact on dementia risk in hypertensive patients. This study aimed to determine the association between coffee and tea consumption and the risk of dementia development in hypertensive population by utilizing Cox proportional risk modeling with 453,913 participants from a UK biobank. Our findings reveal a J-shaped and U-shaped association between the risk of all-cause dementia and the consumption of coffee and tea respectively in hypertensive people. The hypertensive patients who drink 0.5-1 cup of coffee or 4-5 cups of tea per day have the lowest risk of dementia. A U-shaped relationship was observed between daily caffeine consumption and the risk of developing all-cause dementia and vascular dementia in the hypertensive population. Furthermore, the significant association between the amount of coffee and tea consumed and the risk of all-cause and vascular dementia were more likely to be found in hypertensive patients than in the non-hypertensive population.

摘要

许多研究表明,喝咖啡和茶可能与高血压和痴呆的风险有关。关于咖啡和茶对高血压患者痴呆风险的影响,研究有限。本研究旨在通过利用英国生物银行的 453913 名参与者进行 Cox 比例风险建模,确定咖啡和茶的摄入与高血压人群中痴呆发展风险之间的关联。我们的研究结果表明,在高血压患者中,咖啡和茶的摄入与全因痴呆风险之间存在 J 形和 U 形关联。每天喝 0.5-1 杯咖啡或 4-5 杯茶的高血压患者痴呆风险最低。在高血压人群中,每天咖啡因摄入量与全因痴呆和血管性痴呆的风险之间呈 U 形关系。此外,与咖啡和茶的摄入量与全因和血管性痴呆风险之间的显著关联在高血压患者中比在非高血压人群中更有可能被发现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5ab/11387621/2ba091f18dea/41598_2024_71426_Fig1_HTML.jpg

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