Negative association between the neutrophil percentage-to-albumin ratio (NPAR) and psoriasis: a retrospective cross-sectional study.

Among patients with psoriasis, there was not much research regarding the assessment of neutrophil percentage-to-albumin ratio (NPAR) in patients with psoriasis. This cross-sectional study aimed to investigate the association between NPAR and prevalence of psoriasis in US adults. Data from adults aged 20 to 80 years in the National Health and Nutrition Examination Survey (NHANES) from 2003 to 2006 and 2009 to 2014 was utilized. Institutional Review Board approval and documented written consent was obtained from participants by NHANES (Protocol #2005-06). Differences between the groups were further explored. The univariate, multivariate logistic regressions and restricted cubic splines (RCS) regression were used to investigate the correlation between NPAR and psoriasis, with results expressed as odds ratios (OR) and 95% confidence intervals (CI). Subgroup analysis of the associations between NPAR and psoriasis was carried out to investigate if the impact of the NPAR varied among different subgroups. Of the 17,489 adults included in the study, 500 (2.9%) were diagnosed with psoriasis. NPAR (per 10 unit) was negatively associated with prevalence of psoriasis (β = 0.55, 95% CI 0.37, 0.82), after being fully adjusted. A non-linear was observed in the dose-response relationship between NPAR and prevalence of psoriasis (P for non-linearity 0.021). In the subgroup analysis, effect size of NPAR on the presence of psoriasis in subgroups was stable (all P values > 0.05). There exists a stable and strong negative non-linearly association between NPAR and prevalence of psoriasis. The potential role and value in the clinical diagnosis and prognostic assessment of the NPAR in psoriasis calls for further longitudinal studies.