Lee Jong Wook, Lee Hankil, Han Euna, Kang Hye-Young
Graduate Program of Industrial Pharmaceutical Science, Yonsei University, Incheon, South Korea.
College of Pharmacy, Ajou University, Suwon, Gyeonggi-do, South Korea.
PLoS One. 2025 Jan 8;20(1):e0307764. doi: 10.1371/journal.pone.0307764. eCollection 2025.
Incidence of visual impairment (VI) and dyslipidemia is increasing with aging. Although good medication adherence (MA) is a crucial factor in achieving therapeutic goals for dyslipidemia, there is a paucity of studies measuring MA in the visually impaired with dyslipidemia. We investigated whether patients with VI had worse MA to dyslipidemia drugs than non-disabled people and determined the factors affecting MA among patients with VI. Data on dyslipidemia patients with VI were extracted in 2017 from the sample cohort database of the National Health Insurance Service. MA to dyslipidemia drugs was measured for two years based on the proportion of days covered (PDC). Conditional logistic regression analysis was performed to analyze the effect of VI on good MA (PDC ≥0.8). The VI group (0.860) had a larger PDC than the non-disabled group (0.850). The adjusted odds ratio (aOR) for good MA among VI vs. non-disabled individuals was statistically insignificant (1.137, 95% confidence interval:0.958-1.350). Significant factors for poor MA in the VI group were younger age (aOR for 20-39 vs. ≥75 years old: 0.124), lower income (aOR for 9-10th decile (rich) vs. 1-4th decile (poor): 1.771), shorter duration of dyslipidemia (aOR for 1-4 vs. 15 years: 0.416), having lower-level providers sas their main providers (aOR for clinics vs. general/tertiary-care hospitals: 0.545), and having mental diseases (aOR: 0.679). Patients with VI did not have worse MA than non-disabled patients taking dyslipidemia medication.
视力损害(VI)和血脂异常的发生率随着年龄增长而增加。尽管良好的药物依从性(MA)是实现血脂异常治疗目标的关键因素,但针对血脂异常的视力受损者进行药物依从性测量的研究却很少。我们调查了视力受损患者与血脂异常药物的依从性是否比非残疾患者更差,并确定了影响视力受损患者药物依从性的因素。2017年从国家健康保险服务样本队列数据库中提取了视力受损血脂异常患者的数据。基于覆盖天数比例(PDC)对血脂异常药物的依从性进行了两年的测量。进行条件逻辑回归分析以分析视力损害对良好药物依从性(PDC≥0.8)的影响。视力受损组(0.860)的PDC高于非残疾组(0.850)。视力受损者与非残疾者之间良好药物依从性的调整优势比(aOR)在统计学上无显著差异(1.137,95%置信区间:0.958 - 1.350)。视力受损组药物依从性差的显著因素包括年龄较小(20 - 39岁与≥75岁的aOR:0.124)、收入较低(第9 - 10分位数(富裕)与第1 - 4分位数(贫穷)的aOR:1.771)、血脂异常病程较短(1 - 4年与15年的aOR:0.416)、主要医疗服务提供者级别较低(诊所与综合/三级医院的aOR:0.545)以及患有精神疾病(aOR:0.679)。视力受损患者在服用血脂异常药物方面的依从性并不比非残疾患者差。