Qiu Xueling, Sun Lukun, Tang Lu, Jiang Xiaochen, Wang Weifeng, Sun Fan, Sun Chenxi, Song Tianyi
Department of Stomatology, The 960th Hospital of People's Liberation Army of China (PLA), Jinan, China.
School of Nursing, Shandong First Medical University (Shandong Academy Of Medical Sciences), Taian, China.
PLoS One. 2024 Dec 30;19(12):e0316260. doi: 10.1371/journal.pone.0316260. eCollection 2024.
Puncture biopsy is a primary method for obtaining tissue or cell samples from tumors for histopathological diagnosis. However, patients often experience pain, anxiety, and discomfort during the procedure. Virtual reality is a novel technology developed through advancements in computer skill, and it is utilized in healthcare as a cognitive approach to relieve pain and relaxation. However, there is controversy in published trials regarding the efficacy of virtual reality in adults during puncture biopsy. Therefore, a synthesis of objective and accurate data is needed to support the efficacy of virtual reality for pain relief during puncture biopsy in adults.
To identify suitable randomized controlled trials, published literature in eight electronic databases will be searched, including PubMed, Web of Science, Cochrane Library, Scopus, EMBASE, Chinese National Knowledge Infrastructure (CNKI), Wan-fang Data, and Chinese Biomedical Database (CBM). The collected data will be consolidated and subjected to meta-analysis by using RevMan 5.4. Mean difference will describe the continuous variables. 95% confidence intervals (CI) will characterize the interval estimates. Model categories will be selected based on heterogeneity. The quality of the inclusion of randomized controlled trials in terms of methodological quality will be assessed by the Cochrane Risk of Bias Assessment Tool. Additionally, strength and certainty of the evidence will be assessed by the GRADE system.
The following protocol delineates the fundamental process and methodology to be employed in a systematic review and meta-analysis of data pertaining to the efficacy of virtual reality in the context of adult puncture biopsy. The results of the study will furnish healthcare professionals with evidence-based clinical evidence, thereby facilitating sound clinical decision-making and yielding beneficial consequences for the clinical domain.
PROSPERO registration number: CRD42024539303.
穿刺活检是获取肿瘤组织或细胞样本进行组织病理学诊断的主要方法。然而，患者在该过程中常经历疼痛、焦虑和不适。虚拟现实是通过计算机技术进步发展起来的一项新技术，在医疗保健中作为一种缓解疼痛和放松的认知方法被应用。然而，已发表的试验对于虚拟现实在成人穿刺活检过程中的疗效存在争议。因此，需要综合客观准确的数据来支持虚拟现实在成人穿刺活检中缓解疼痛的疗效。
为识别合适的随机对照试验，将检索八个电子数据库中的已发表文献，包括PubMed、科学网、考克兰图书馆、Scopus、EMBASE、中国知网、万方数据和中国生物医学数据库（CBM）。收集的数据将进行整合，并使用RevMan 5.4进行荟萃分析。均数差将描述连续变量。95%置信区间（CI）将表征区间估计。将根据异质性选择模型类别。将通过考克兰偏倚风险评估工具评估纳入的随机对照试验在方法学质量方面的纳入质量。此外，将通过GRADE系统评估证据的强度和确定性。
以下方案描述了在对虚拟现实在成人穿刺活检中的疗效相关数据进行系统评价和荟萃分析时所采用的基本过程和方法。该研究结果将为医疗保健专业人员提供循证临床证据，从而促进合理的临床决策，并为临床领域带来有益的结果。
PROSPERO注册号：CRD42024539303。
