Kunming Municipal Hospital of Traditional Chinese Medicine, The Third Affiliated Hospital of Yunnan University of Chinese Medicine, Kunming, Yunnan Province, China.
Haikou Orthopedic and Diabetes Hospital of Shanghai Sixth People's Hospital, Haikou, Hainan Province, China.
PLoS One. 2024 Nov 7;19(11):e0313296. doi: 10.1371/journal.pone.0313296. eCollection 2024.
Upper extremity deficits (UED) is a common and impactful complication among stroke survivors. Virtual reality (VR)-based rehabilitation holds potential for enhancing rehabilitation intensity and engagement by stimulating tasks. While several clinical studies have examined the effectiveness and safety of VR-based rehabilitation, there is a need for further research to improve consistency in outcomes.
The study will incorporate randomized controlled trials (RCTs) concerning the effects of VR-based rehabilitation on upper extremity (UE) function in stroke survivors. A comprehensive search of databases including PubMed, Embase, Cochrane Library, Web of Science, Scopus, Cinahl, China National Knowledge Infrastructure (CNKI), Wan-fang, and Chinese Biology Medicine Database will be performed from inception to the start of the study. Primary outcomes will focus on upper limb motor function assessments such as the Fugl-Meyer Upper Extremity (FMUE), Box and Block Test (BBT), Wolf Motor Function Test (WMFT), and Action Research Arm Test (ARAT). Secondary outcomes related to activities of daily living will include the Barthel Index (BI) and Functional Independence Measure (FIM). Research selection, data extraction, and quality assessment will be independently conducted by two researchers. The recently revised Cochrane risk of bias tool will be employed to evaluate study quality. Meta-regression and subgroup analyses will be utilized to identify effective therapy delivery modes and patterns. The assessment, development, and evaluation of recommendations approach will be applied to achieve a robust conclusion.
This study provides a rigorous synthesis to evaluate optimal parameters-specifically intensity and duration-for VR-based rehabilitation interventions aimed at enhancing UE function in stroke survivors. Our secondary objective is to assess the impact of these parameters on rehabilitation outcomes. We anticipate an accurate, transparent, and standardized review process that will yield evidence-based recommendations for integrating VR technology into treating upper extremity dysfunction in stroke patients, offering clinicians effective strategies to enhance upper limb function.
上肢功能缺损（UED）是脑卒中幸存者常见且影响较大的并发症。基于虚拟现实（VR）的康复通过刺激任务，具有提高康复强度和参与度的潜力。虽然已经有几项临床研究检查了基于 VR 的康复对脑卒中幸存者上肢功能的有效性和安全性，但需要进一步研究以提高结果的一致性。
该研究将纳入关于基于 VR 的康复对脑卒中幸存者上肢功能影响的随机对照试验（RCT）。将全面检索包括 PubMed、Embase、Cochrane 图书馆、Web of Science、Scopus、CINHAL、中国国家知识基础设施（CNKI）、万方和中国生物医学文献数据库在内的数据库，检索时间从研究开始到研究开始。主要结局将集中在上肢运动功能评估，如 Fugl-Meyer 上肢评估（FMUE）、箱式和块式测试（BBT）、Wolf 运动功能测试（WMFT）和动作研究上肢测试（ARAT）。与日常生活活动相关的次要结局将包括 Barthel 指数（BI）和功能独立性测量（FIM）。研究选择、数据提取和质量评估将由两名研究人员独立进行。将采用最近修订的 Cochrane 偏倚风险工具评估研究质量。Meta 回归和亚组分析将用于确定有效的治疗传递模式和模式。将应用评估、开发和评估建议方法来得出强有力的结论。
本研究通过严格的综合评估，旨在评估针对脑卒中幸存者上肢功能的基于 VR 的康复干预的最佳参数，特别是强度和持续时间。我们的次要目标是评估这些参数对康复结果的影响。我们预计会有一个准确、透明和标准化的审查过程，为将 VR 技术整合到治疗脑卒中患者上肢功能障碍中提供基于证据的建议，为临床医生提供增强上肢功能的有效策略。
