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基于参考点云配准的三维徒手超声重建

3d freehand ultrasound reconstruction by reference-based point cloud registration.

作者信息

Großbröhmer Christoph, Hansen Lasse, Lichtenstein Jürgen, Tüshaus Ludger, Heinrich Mattias P

机构信息

Institute of Medical Informatics, University of Lübeck, Lübeck, Germany.

EchoScout GmbH, Lübeck, Germany.

出版信息

Int J Comput Assist Radiol Surg. 2025 Mar;20(3):475-484. doi: 10.1007/s11548-024-03280-2. Epub 2025 Jan 7.

DOI:10.1007/s11548-024-03280-2
PMID:39775631
Abstract

PURPOSE

This study aims to address the challenging estimation of trajectories from freehand ultrasound examinations by means of registration of automatically generated surface points. Current approaches to inter-sweep point cloud registration can be improved by incorporating heatmap predictions, but practical challenges such as label-sparsity or only partially overlapping coverage of target structures arise when applying realistic examination conditions.

METHODS

We propose a pipeline comprising three stages: (1) Utilizing a Free Point Transformer for coarse pre-registration, (2) Introducing HeatReg for further refinement using support point clouds, and (3) Employing instance optimization to enhance predicted displacements. Key techniques include expanding point sets with support points derived from prior knowledge and leverage of gradient keypoints. We evaluate our method on a large set of 42 forearm ultrasound sweeps with optical ground-truth tracking and investigate multiple ablations.

RESULTS

The proposed pipeline effectively registers free-hand intra-patient ultrasound sweeps. Combining Free Point Transformer with support-point enhanced HeatReg outperforms the FPT baseline by a mean directed surface distance of 0.96 mm (40%). Subsequent refinement using Adam instance optimization and DiVRoC further improves registration accuracy and trajectory estimation.

CONCLUSION

The proposed techniques enable and improve the application of point cloud registration as a basis for freehand ultrasound reconstruction. Our results demonstrate significant theoretical and practical advantages of heatmap incorporation and multi-stage model predictions.

摘要

目的

本研究旨在通过自动生成的表面点配准来解决徒手超声检查中具有挑战性的轨迹估计问题。通过纳入热图预测可以改进当前的跨扫描点云配准方法,但在应用实际检查条件时会出现诸如标签稀疏或目标结构覆盖仅部分重叠等实际挑战。

方法

我们提出了一个包含三个阶段的流程:(1)使用自由点变换器进行粗预配准,(2)引入HeatReg使用支持点云进行进一步细化,以及(3)采用实例优化来增强预测位移。关键技术包括用从先验知识导出的支持点扩展点集以及利用梯度关键点。我们在一大组42次前臂超声扫描上使用光学地面真值跟踪评估我们的方法,并研究多种消融情况。

结果

所提出的流程有效地配准了患者体内的徒手超声扫描。将自由点变换器与支持点增强的HeatReg相结合,平均定向表面距离比FPT基线提高了0.96毫米(40%)。随后使用Adam实例优化和DiVRoC进行细化进一步提高了配准精度和轨迹估计。

结论

所提出的技术实现并改进了点云配准作为徒手超声重建基础的应用。我们的结果证明了纳入热图和多阶段模型预测的显著理论和实际优势。

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本文引用的文献

1
Real-time multimodal image registration with partial intraoperative point-set data.基于部分术中点集数据的实时多模态图像配准。
Med Image Anal. 2021 Dec;74:102231. doi: 10.1016/j.media.2021.102231. Epub 2021 Sep 21.
2
nnU-Net: a self-configuring method for deep learning-based biomedical image segmentation.nnU-Net:一种基于深度学习的生物医学图像分割的自配置方法。
Nat Methods. 2021 Feb;18(2):203-211. doi: 10.1038/s41592-020-01008-z. Epub 2020 Dec 7.
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3D freehand ultrasound without external tracking using deep learning.基于深度学习的无外部追踪的 3D 自由式超声。
Med Image Anal. 2018 Aug;48:187-202. doi: 10.1016/j.media.2018.06.003. Epub 2018 Jun 15.
4
Ultrasound registration: A review.超声配准:综述
Methods. 2017 Feb 15;115:128-143. doi: 10.1016/j.ymeth.2016.12.006. Epub 2016 Dec 11.