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初始抗CD19嵌合抗原受体T细胞疗法对复发/难治性大B细胞淋巴瘤患者后续抗CD22嵌合抗原受体T细胞制备及临床结局的影响

Effects of an Initial Anti-CD19 CAR T-cell Therapy on Subsequent Anti-CD22 CAR T-cell Manufacturing and Clinical Outcomes in Patients with Relapsed/Refractory LBCL.

作者信息

Su Yi-Jiun, Kramer Anne Marijn, Hamilton Mark P, Agarwal Neha, Srinagesh Hrishikesh K, Baird John H, Sahaf Bita, Kuo Adam, Ehlinger Zachary J, Desai Moksha H, Rietberg Skyler P, Tunuguntla Ramya, Patel Shabnum, Chinnasamy Harshini, Gkitsas-Long Nikolaos, Klysz Dorota D, Brown Annie Kathleen, Bharadwaj Sushma, Dahiya Saurabh, Smith Melody, Muffly Lori, Mackall Crystal L, Good Zinaida, Feldman Steven A, Miklos David B, Frank Matthew J

机构信息

Division of Blood and Marrow Transplantation and Cellular Therapy, Stanford University School of Medicine, Stanford, California.

Division of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.

出版信息

Cancer Discov. 2025 Apr 2;15(4):733-747. doi: 10.1158/2159-8290.CD-24-1071.

DOI:10.1158/2159-8290.CD-24-1071
PMID:39775812
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11964843/
Abstract

Late leukapheresis (>6 months after CAR19) resulted in less residual CAR19, higher CAR22 CD4+ naïve T and TCM cells, less TEM cells, and higher CD8+ TCM cells, but similar clinical outcomes to those with early leukapheresis. CAR22 responses were associated with higher transduction efficiency and CD8+ TCM and less CD8+ TEM cells.

摘要

晚期白细胞单采术（嵌合抗原受体19 [CAR19] 后>6个月）导致残留的CAR19较少、CAR22 CD4+初始T细胞和中央记忆T细胞较多、效应记忆T细胞较少以及CD8+中央记忆T细胞较多，但临床结果与早期白细胞单采术相似。CAR22反应与更高的转导效率、CD8+中央记忆T细胞以及更少的CD8+效应记忆T细胞相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f325/11964843/e44d0a6b5365/nihms-2049831-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f325/11964843/4ce2d495b90e/nihms-2049831-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f325/11964843/ff4e37f0e1ec/nihms-2049831-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f325/11964843/038a8fda9e39/nihms-2049831-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f325/11964843/a75dc2588107/nihms-2049831-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f325/11964843/e44d0a6b5365/nihms-2049831-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f325/11964843/4ce2d495b90e/nihms-2049831-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f325/11964843/ff4e37f0e1ec/nihms-2049831-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f325/11964843/038a8fda9e39/nihms-2049831-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f325/11964843/a75dc2588107/nihms-2049831-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f325/11964843/e44d0a6b5365/nihms-2049831-f0005.jpg

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