Wyllie E, Lueders H, Pippenger C, VanLente F
Arch Neurol. 1985 Feb;42(2):123-6. doi: 10.1001/archneur.1985.04060020033010.
We prospectively correlated daily serum creatine kinase (CK) levels with the occurrence of different types of epileptic and nonepileptic seizures documented by video EEG recording in 22 hospitalized patients. Prolonged postictal CK elevations, 8.0 to 19.2 times baseline, were seen following six (15%) of 41 generalized tonoclonic seizures. No CK elevations were seen following 147 complex partial, focal motor, absence, and tonic seizures or 55 psychogenic seizures, 89% of which involved vigorous muscular activity. Six of 12 patients with generalized tonoclonic seizures had postictal CK elevations compared with none of six patients with psychogenic seizures and none of 15 patients with complex partial, focal motor, absence, and tonic seizures. Thus, postictal CK determination can serve as an adjunctive test for differentiation between psychogenic and epileptic generalized tonoclonic seizures.
我们前瞻性地将22例住院患者每日血清肌酸激酶（CK）水平与视频脑电图记录所证实的不同类型癫痫发作和非癫痫发作的发生情况进行了关联分析。在41次全身性强直阵挛发作中的6次（15%）发作后，观察到发作后CK水平长时间升高，为基线水平的8.0至19.2倍。在147次复杂部分性发作、局灶性运动性发作、失神发作和强直性发作或55次心因性发作后未观察到CK水平升高，其中89%的心因性发作涉及剧烈肌肉活动。12例全身性强直阵挛发作患者中有6例发作后CK水平升高，相比之下，6例心因性发作患者和15例复杂部分性发作、局灶性运动性发作、失神发作和强直性发作患者均未出现这种情况。因此，发作后CK测定可作为鉴别心因性和癫痫性全身性强直阵挛发作的辅助检查。
