Wei Cunbao, Sun Xingwei, Li Shenzhi, Bai Xuming, Jin Yong
Department of Radiology, The Third People's Hospital of Dafeng District, Yancheng, China.
Department of Interventional Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Discov Oncol. 2025 Jan 7;16(1):14. doi: 10.1007/s12672-025-01737-7.
The aim of this study was to comparatively analyze the therapeutic effects of uterine artery embolization (UAE) and laparoscopic myomectomy (LM) on uterine fibroids to determine which treatment method is more beneficial for patients.
A retrospective study was conducted on 396 patients who underwent UAE (n = 153) or LM (n = 243) treatment from April 2010 to September 2019. After 1:1 propensity score matching (PSM), a comparative analysis was conducted on surgical trauma magnitude, postoperative recovery time, improvement in associated symptoms and quality of life, surgical adverse events, recurrence rates, and further interventions.
In PSM, 66 pairs (132 patients) were successfully matched. Both treatments significantly alleviated symptoms and enhanced quality of life. Compared to the LM group, the UAE group had less intraoperative bleeding (P < 0.001), a lower rate of hemoglobin decrease (P < 0.001), shorter operation, postoperative, and overall hospital stays (P < 0.001), and a lower postoperative recurrence rate (P < 0.05), all statistically significant. Moreover, the UAE group showed notable advantages in postoperative activities (P < 0.05). However, UAE patients faced higher hospitalization costs (P < 0.001). Adverse event rates (7.6% vs. 9.1%) and postoperative reintervention rates (7.6% vs. 7.6%) were relatively low and not significantly different between groups (P > 0.05).
Both UAE and LM can significantly improve patient symptoms and enhance their quality of life, and both treatment methods have low rates of adverse events and reinterventions. Compared to LM, UAE treatment for uterine fibroids presents advantages such as less trauma, faster recovery, and lower recurrence rate, but has higher treatment costs.
本研究旨在比较分析子宫动脉栓塞术（UAE）和腹腔镜子宫肌瘤切除术（LM）对子宫肌瘤的治疗效果，以确定哪种治疗方法对患者更有益。
对2010年4月至2019年9月期间接受UAE治疗（n = 153）或LM治疗（n = 243）的396例患者进行回顾性研究。经过1:1倾向评分匹配（PSM）后，对手术创伤大小、术后恢复时间、相关症状改善情况和生活质量、手术不良事件、复发率及进一步干预措施进行比较分析。
在PSM中，成功匹配66对（132例患者）。两种治疗均能显著缓解症状并提高生活质量。与LM组相比，UAE组术中出血更少（P < 0.001），血红蛋白下降率更低（P < 0.001），手术、术后及总住院时间更短（P < 0.001），术后复发率更低（P < 0.05），差异均有统计学意义。此外，UAE组在术后活动方面具有显著优势（P < 0.05）。然而，UAE治疗的患者住院费用更高（P < 0.001）。不良事件发生率（7.6%对9.1%）和术后再次干预率（7.6%对7.6%）相对较低，两组间差异无统计学意义（P > 0.05）。
UAE和LM均能显著改善患者症状并提高生活质量，两种治疗方法的不良事件和再次干预率均较低。与LM相比，UAE治疗子宫肌瘤具有创伤小、恢复快、复发率低等优势，但治疗费用较高。
