School of Public Health, Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Chongqing, 400016, People's Republic of China.
State Key Laboratory of Ultrasound in Medicine and Engineering, Chongqing Medical University, Chongqing, People's Republic of China.
BMC Womens Health. 2022 Sep 10;22(1):372. doi: 10.1186/s12905-022-01963-z.
To demonstrate the applicability and adaptability of uterine fibroid symptoms and quality of life (UFS-QoL) in assessing the efficacy of treatment in Chinese populations.
This is a secondary analysis of a prospective cohort study involving 20 Chinese hospitals and 2,411 Chinese women with fibroids. Patients completed UFS-QoL and short form-36 (SF-36) at pre-surgery, 6-month and 12-month post-treatments. Internal consistency of the quality of life assessed by the UFS-QoL questionnaire using Cronbach's α coefficient (α). Principal axis factor analysis with orthogonal rotation was established to investigate relationships between items and subscales. Concurrent validity refers to the Spearman's correlation estimate of the correlation between UFS-QoL and SF-36. Using effect size and standardized response mean, the ability to detect change was evaluated by comparing pre- and post-6-month and post-12-month treatment scores.
Exploratory factor analysis yielded six subscales (concern, activities, energy/mood, control, self-consciousness, and sexual function) with eigenvalues > 1 in UFS-QoL. A 63.61% total variance was explained by the test items. Ceiling effects of self-consciousness and sexual functioning subscales from UFS-QoL were > 15%. UFS-QoL showed a positive and moderate correlation with SF-36 to establish good concurrent validity. And showed good consistency reliability (Cronbach α > 0.7 in all subscales), ability to detect change after treatment. This excluded self-consciousness (α = 0.56), which demonstrated the lowest effect size (0.38) and standardized response means (0.38) 6- and 12-months post-treatment.
Symptom severity, activity, and mood subscales of the Chinese UFS-QoL were valid and reliable. However, the self-consciousness domain needs further investigation on cultural adaptation, such as cognitive debriefing for how Chinese interpret these questions.
展示子宫肌瘤症状和生活质量问卷（UFS-QoL）在评估中国人群治疗效果中的适用性和可适应性。
这是一项前瞻性队列研究的二次分析，涉及 20 家中国医院和 2411 名中国子宫肌瘤患者。患者在术前、术后 6 个月和 12 个月分别完成 UFS-QoL 和简明健康状况调查问卷 36 项（SF-36）。采用 Cronbach's α 系数（α）评估 UFS-QoL 问卷的生活质量内部一致性。建立主轴因子分析，采用正交旋转，研究项目与亚量表之间的关系。同时效度是指 UFS-QoL 与 SF-36 之间的相关的 Spearman 相关估计值。通过比较治疗前与治疗后 6 个月和 12 个月的评分，采用效应量和标准化反应均数，评估检测变化的能力。
UFS-QoL 中的探索性因子分析产生了六个亚量表（担忧、活动、能量/情绪、控制、自我意识和性功能），特征值均大于 1。测试项目解释了 63.61%的总方差。UFS-QoL 自我意识和性功能亚量表的天花板效应大于 15%。UFS-QoL 与 SF-36 呈正相关，具有中度相关性，建立了良好的同时效度。并且在所有亚量表中均表现出良好的一致性可靠性（Cronbach α值均大于 0.7），治疗后具有检测变化的能力。除自我意识外（治疗后 6 个月和 12 个月的 Cronbach α 值分别为 0.56），该量表具有最低的效应量（0.38）和标准化反应均数（0.38）。
中国 UFS-QoL 的症状严重程度、活动和情绪亚量表具有有效性和可靠性。然而，自我意识领域需要进一步研究文化适应性，例如对中国人如何解释这些问题进行认知剖析。
