Wang Yao, Lin Meng, Fan Tianfei, Zhou Minglu, Yin Ruxi, Wang Xueyan
Department of pharmacy, west china hospital, Sichuan University, Chengdu, 610041, People's Republic of China.
Int J Nanomedicine. 2025 Jan 1;20:1-24. doi: 10.2147/IJN.S495387. eCollection 2025.
Amphiphilic copolymers are composed of both hydrophilic and hydrophobic chains, which can self-assemble into polymeric micelles in aqueous solution via the hydrophilic/hydrophobic interactions. Due to their unique properties, polymeric micelles have been widely used as drug carriers. Poorly soluble drugs can be covalently attached to polymer chains or non-covalently incorporated in the micelles, with improved pharmacokinetic profiles and enhanced efficacy. In recent years, stimuli-responsive amphiphilic copolymer micelles have attracted significant attention. These micelles can respond to specific stimuli, including physical triggers (light, temperature, etc). chemical stimuli (pH, redox, etc). and physiological factors (enzymes, ATP, etc). Under these stimuli, the structures or properties of the micelles can change, enabling targeted therapy and controlled drug release in tumors. These stimuli-responsive strategies offer new avenues and approaches to enhance the tumor efficacy and reduce drug side effects. We will review the applications of different types of stimuli-responsive amphiphilic copolymer micelles in tumor therapy, aiming to provide valuable guidance for future research directions and clinical translation.
两亲性共聚物由亲水链和疏水链组成，它们可通过亲水/疏水相互作用在水溶液中自组装成聚合物胶束。由于其独特的性质，聚合物胶束已被广泛用作药物载体。难溶性药物可共价连接到聚合物链上或非共价包封在胶束中，从而改善药代动力学特征并增强疗效。近年来，刺激响应性两亲性共聚物胶束引起了广泛关注。这些胶束可对特定刺激做出响应，包括物理触发因素（光、温度等）、化学刺激（pH值、氧化还原等）和生理因素（酶、ATP等）。在这些刺激下，胶束的结构或性质会发生变化，从而实现肿瘤的靶向治疗和药物的控释。这些刺激响应策略为提高肿瘤疗效和降低药物副作用提供了新的途径和方法。我们将综述不同类型的刺激响应性两亲性共聚物胶束在肿瘤治疗中的应用，旨在为未来的研究方向和临床转化提供有价值的指导。
