Spiker Andrea M, Choe Joshua A, Turner Elizabeth H G, Vanderby Ray, Murphy William L, Chamberlain Connie S
Department of Orthopedic Surgery, University of Wisconsin - Madison, Madison, Wisconsin, U.S.A.
Department of Biomedical Engineering, University of Wisconsin - Madison, Madison, Wisconsin, U.S.A.
Arthrosc Sports Med Rehabil. 2024 Jul 30;6(6):100985. doi: 10.1016/j.asmr.2024.100985. eCollection 2024 Dec.
PURPOSE: To identify key molecular components within the femoroacetabular impingement hip and compare the findings between male and female patients across varying age groups. METHODS: All patients undergoing hip arthroscopy for femoroacetabular impingement syndrome (FAIS) without hip dysplasia were included. During hip arthroscopy, performed at University of Wisconsin Health, loose articular cartilage, excess synovium, damaged labral tissue, and minimal adipose tissue were debrided only as needed for visualization and tissue repair purposes and collected. Tissue was processed and used for quantitative polymerase chain reaction (qPCR). Genes were selected for qPCR on the basis of their associated function in inflammation and/or extracellular matrix remodeling during the progression of osteoarthritis. RESULTS: A total of 91 male (M) and female (F) patients 15 to 58 years old were included in the study. qPCR results indicated that Interleukin-6 ( < .05, 95% confidence interval [CI] 0.047-0.083 F, 0.070-0.12 M) and Interleukin-8 ( = .04, 95% CI 0.059-0.10 F, 0.082-0.18 M) were significantly greater in male patients compared with female patients regardless of age, and ( = .02, 95% CI [0.026-0.070] F, [0.067-0.17] M), Interleukin-1ß ( < .01 95% CI [0.013-0.063] F, [0.073-0.25] M), and Matrix metalloproteinase-13 ( = .047, 95% CI [0.0051-0.017] F, [0.0084-0.052] M) were significantly greater in male patients younger than 20 years old compared with female patients younger than 20 years old. CONCLUSIONS: In patients with FAIS, there are significant differences between male and female patients in the biomarkers present in the affected hip at the time of surgery. Male patients have greater levels of and and male patients younger than 20 years of age have greater levels of , , and compared with age-matched female patients. CLINICAL RELEVANCE: A better understanding of the molecular markers present during varying stages of FAIS and in patients of different ages will help characterize the pathologic process behind FAIS. This may also help define future methods of targeted treatment and prevention of disease progression.
目的：确定股骨髋臼撞击综合征髋关节内的关键分子成分，并比较不同年龄组男性和女性患者的研究结果。 方法：纳入所有因股骨髋臼撞击综合征（FAIS）接受髋关节镜检查且无髋关节发育不良的患者。在威斯康星大学健康中心进行髋关节镜检查时，仅在为了可视化和组织修复需要时清理松动的关节软骨、多余的滑膜、受损的盂唇组织和少量脂肪组织，并收集这些组织。对组织进行处理并用于定量聚合酶链反应（qPCR）。根据基因在骨关节炎进展过程中与炎症和/或细胞外基质重塑相关的功能来选择用于qPCR的基因。 结果：共有91名年龄在15至58岁之间的男性（M）和女性（F）患者纳入本研究。qPCR结果表明，无论年龄如何，男性患者的白细胞介素-6（P <.05，95%置信区间[CI] 0.047 - 0.083 F，0.070 - 0.12 M）和白细胞介素-8（P = 0.04，95% CI 0.059 - 0.10 F，0.082 - 0.18 M）均显著高于女性患者；且（P = 0.02，95% CI [0.026 - 0.070] F，[0.067 - 0.17] M）、白细胞介素-1β（P <.01，95% CI [0.013 - 0.063] F，[0.073 - 0.25] M）以及基质金属蛋白酶-13（P = 0.047，95% CI [0.0051 - 0.017] F，[0.0084 - 0.052] M）在20岁以下的男性患者中显著高于20岁以下的女性患者。 结论：在FAIS患者中，男性和女性患者在手术时患侧髋关节中存在的生物标志物有显著差异。与年龄匹配的女性患者相比，男性患者的[具体物质1]和[具体物质2]水平更高，20岁以下的男性患者的[具体物质3]、[具体物质4]和[具体物质5]水平更高。 临床意义：更好地了解FAIS不同阶段以及不同年龄患者中存在的分子标志物，将有助于描述FAIS背后的病理过程。这也可能有助于确定未来针对性治疗和预防疾病进展的方法。
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