1例慢性淋巴细胞白血病在伊布替尼治疗期间转化为华氏巨球蛋白血症的罕见病例。
A Rare Case of Chronic Lymphocytic Leukemia Transforming Into Waldenström Macroglobulinemia During Ibrutinib Therapy.
作者信息
Samsuddoha Kazi, Homsy Sylvester, Preet Mohan, Naher Kamrun
机构信息
Internal Medicine, State University of New York Downstate Medical Center, Brooklyn, USA.
Hematology and Oncology, State University of New York Downstate Medical Center, Brooklyn, USA.
出版信息
Cureus. 2024 Dec 7;16(12):e75274. doi: 10.7759/cureus.75274. eCollection 2024 Dec.
Abstract
Chronic lymphocytic leukemia (CLL) can rarely transform into Waldenström macroglobulinemia (WM), posing diagnostic and therapeutic challenges. The diagnosis of WM requires bone marrow infiltration by lymphoplasmacytic cells and the presence of IgM gammopathy. Immunophenotypic markers include FMC7+, CD19+, CD20+, and CD138+. The MYD88 mutation is characteristic. Symptoms arise from tumor infiltration and monoclonal protein production. Here, we present a case of CLL transforming into WM during treatment with ibrutinib. Given the rarity of such a transformation, this case may serve as a valuable reference, and further investigation is needed to understand the pathology underlying this transformation.
摘要
慢性淋巴细胞白血病（CLL）很少会转化为华氏巨球蛋白血症（WM），这带来了诊断和治疗方面的挑战。WM的诊断需要骨髓被淋巴浆细胞浸润以及存在IgM型丙种球蛋白病。免疫表型标志物包括FMC7+、CD19+、CD20+和CD138+。MYD88突变是其特征性表现。症状由肿瘤浸润和单克隆蛋白产生引起。在此，我们报告一例在接受依鲁替尼治疗期间CLL转化为WM的病例。鉴于这种转化非常罕见，该病例可能会成为有价值的参考，并且需要进一步研究以了解这种转化背后的病理机制。
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