Jackson Catherine A, McKean Elise L, Hawdon John M
Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, Washington, D.C., United States.
Biological Sciences, George Washington University, Washington, Washington, D.C., United States.
MicroPubl Biol. 2024 Dec 24;2024. doi: 10.17912/micropub.biology.001360. eCollection 2024.
This study explores potential small animal models for the dog hookworm, , a parasitic nematode which has repeatedly exhibited the ability to develop resistance to a range of anthelmintics. Immunomodulated hamsters, gerbils, rats, and mice were infected with Despite varying degrees of immunosuppression, and in some cases, total adaptive immunodeficiency, no adult worms were recovered, and larval arrest (L3 stage) occurred in muscle tissue of mice and hamsters. This highlights the strict host specificity of and emphasizes the challenges of developing rodent models usable for anthelmintic testing with a strict specialist parasite.
本研究探索了犬钩虫（一种寄生线虫）潜在的小动物模型，该寄生虫已多次表现出对一系列驱虫药产生抗性的能力。对免疫调节的仓鼠、沙鼠、大鼠和小鼠感染了[此处原文缺失感染的具体内容]。尽管存在不同程度的免疫抑制，在某些情况下甚至存在完全的适应性免疫缺陷，但未发现成虫，并且在小鼠和仓鼠的肌肉组织中出现了幼虫停滞（L3期）。这突出了[此处原文缺失寄生虫名称]严格的宿主特异性，并强调了开发可用于严格专性寄生虫驱虫药测试的啮齿动物模型所面临的挑战。
