Khorraminejad-Shirazi Mohammadhossein, Nabavizadeh Ali, Bojnoordi Anita, Firouzabadi Dena, Rakhsha Abbas, Hosseini Seyed Ali, Dehghanian Amirreza
Department of Pathology, School of Medicine Jahrom University of Medical Sciences Jahrom Iran.
Department of Pathology, School of Medicine Shiraz University of Medical Sciences Shiraz Iran.
Clin Case Rep. 2025 Jan 6;13(1):e70073. doi: 10.1002/ccr3.70073. eCollection 2025 Jan.
Osteoblastoma is an uncommon benign bone tumor rarely involving the craniofacial skeleton. Manifestations in the fronto-orbital region are exceptionally rare. A 19-year-old man presented with persistent headache, nausea, vomiting, right eye pain, and longstanding right exophthalmos. Imaging revealed a heterogeneous enhancing lesion located in the right anterior cranial fossa-orbital apex junction causing pressure on the orbital roof. Differential diagnoses included fibrous dysplasia and meningioma. The tumor was resected via frontal craniotomy. Definitive diagnosis of osteoblastoma was achieved postoperatively through histopathological examination and IHC studies. Craniofacial osteoblastomas, especially in the fronto-orbital region, are exceptionally rare and may present radiological features similar to other bone pathologies. Accurate diagnosis hinges on histopathological evaluation. A multidisciplinary approach is pivotal for successful diagnosis and treatment of such challenging cases.
骨母细胞瘤是一种罕见的良性骨肿瘤，很少累及颅面骨骼。额眶区域的表现极为罕见。一名19岁男性出现持续性头痛、恶心、呕吐、右眼疼痛和长期的右眼球突出。影像学检查显示一个位于右前颅窝-眶尖交界处的不均匀强化病变，对眶顶产生压迫。鉴别诊断包括骨纤维发育不良和脑膜瘤。通过额部开颅手术切除肿瘤。术后通过组织病理学检查和免疫组化研究确诊为骨母细胞瘤。颅面骨母细胞瘤，尤其是在额眶区域，极为罕见，可能呈现与其他骨病变相似的放射学特征。准确的诊断取决于组织病理学评估。多学科方法对于成功诊断和治疗此类具有挑战性的病例至关重要。
