Otolaryngology Section, Department of Medicine and Surgery, University of Catania, Italy.
Eur Rev Med Pharmacol Sci. 2012 Nov;16(13):1891-4.
Osteoblastoma is a solitary, benign bone tumor that is rarely localized in the frontal sinus. It consists of hypocellular mineralized tissue that may form large masses or irregular trabeculae. A 31 year old man came to our attention with a 7 month history of diplopia, photophobia, frontal headhaches and progressive exophthalmos with proptosis of the left eye. The patient was submitted to computed tomography (CT) which allowed to appraise the extension of the lesion. The mass expanded inside the left frontal sinus and the upper ethmoidal cells invading the left orbital roof. Considering the extension of the tumor, the site and the connections with contiguous structures, a combination of endoscopic endonasal technique with intraorbital approach was performed. At histological examination typical features of benign osteoblastoma were observed. The sites of predilection for the tumor are the long bones, vertebral column, and small bones of hands and feet. Its occurrence in the skull and jaw bones is relatively rare and represents only 15% of all osteoblastomas. To our knowledge, only 5 cases of osteoblastoma of the frontal sinus have been previously reported in the English-language literature. This report describes a case of benign osteoblastoma in a rare site, namely, the frontal sinus with particular attention about the differential diagnosis and the treatment.
骨母细胞瘤是一种孤立的良性骨肿瘤，很少局限于额窦。它由细胞稀少的矿化组织组成，可能形成大肿块或不规则的小梁。一名 31 岁男性因复视、畏光、额头痛和左眼进行性眼球突出伴突出来我院就诊。患者行计算机断层扫描（CT）检查，评估病变的范围。肿块在左额窦内扩大，筛窦上部细胞侵犯左眼眶顶。考虑到肿瘤的范围、部位以及与相邻结构的关系，采用了经鼻内镜联合眶内入路的联合治疗。组织学检查观察到典型的良性骨母细胞瘤特征。肿瘤的好发部位为长骨、脊柱和手足小骨。其在颅骨和颌骨中的发生相对少见，仅占所有骨母细胞瘤的 15%。据我们所知，英文文献中仅报道过 5 例额窦骨母细胞瘤。本报告描述了一例罕见部位（即额窦）的良性骨母细胞瘤，特别关注鉴别诊断和治疗。
