Yan Ke, Zhang Qinghe, Liu Qiuping, Han Yi, Liu Zuguo
Department of Ophthalmology, The First Affiliated Hospital of University of South China, Hengyang Medical School, University of South China, Hengyang Hunan 421001, China.
Xiamen University affiliated Xiamen Eye Center, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Fujian Engineering and Research Center of Eye Regenerative Medicine, Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen Fujian 361005, China.
Theranostics. 2025 Jan 1;15(3):915-942. doi: 10.7150/thno.103266. eCollection 2025.
Adhesive hydrogels, composed of hydrophilic polymers arranged in a three-dimensional network, have emerged as a pivotal innovation in ophthalmology due to their ability to securely adhere to ocular tissues while providing sustained therapeutic effects. The eye, with its delicate structure and specific needs, presents unique challenges for drug delivery and tissue regeneration. This review explores the transformative potential of adhesive hydrogels in addressing these challenges across a range of ocular conditions, including corneal injuries, cataracts, glaucoma, vitreoretinal disorders, and ocular trauma. By detailing the mechanisms of polymerization and adhesion, this paper highlights how these materials can be customized for specific ophthalmic applications, offering insights into their current use and future possibilities. The emphasis is placed on the clinical significance and future directions of adhesive hydrogels in advancing ophthalmic therapy, potentially revolutionizing the treatment of complex eye diseases.
粘性水凝胶由排列成三维网络的亲水性聚合物组成，由于其能够牢固地粘附于眼部组织并提供持续治疗效果，已成为眼科领域的一项关键创新。眼睛结构精细且有特定需求，在药物递送和组织再生方面面临独特挑战。本综述探讨了粘性水凝胶在应对一系列眼部疾病（包括角膜损伤、白内障、青光眼、玻璃体视网膜疾病和眼外伤）挑战方面的变革潜力。通过详细阐述聚合和粘附机制，本文强调了这些材料如何针对特定眼科应用进行定制，深入了解其当前用途和未来可能性。重点在于粘性水凝胶在推进眼科治疗方面的临床意义和未来方向，这可能会彻底改变复杂眼病的治疗方式。
