Wickramasinghe Nilanka, Devanarayana Niranga Manjuri
Department of Physiology, Faculty of Medicine, University of Colombo, Colombo 00800, Western Province, Sri Lanka.
Department of Physiology, Faculty of Medicine, University of Kelaniya, Ragama 11010, Western Province, Sri Lanka.
World J Gastroenterol. 2025 Jan 7;31(1):98479. doi: 10.3748/wjg.v31.i1.98479.
Gastroesophageal reflux disease (GERD) poses a substantial global health challenge, with prevalence rates exhibiting geographical variation. Despite its widespread recognition, the exact prevalence and associated risk factors remain elusive. This article comprehensively analyzed the global burden of GERD, shedding light on its risk factors, underlying pathophysiological mechanisms, current diagnostic modalities, evolving management strategies tailored to diverse patient profiles, and complex determinants contributing to treatment failures. A deeper comprehension of GERD is achieved by dissecting these intricate facets, paving the way for enhanced clinical management and improved patient outcomes.
胃食管反流病（GERD）是一项重大的全球健康挑战，其患病率存在地域差异。尽管已得到广泛认识，但其确切患病率及相关危险因素仍不明确。本文全面分析了GERD的全球负担，阐明了其危险因素、潜在病理生理机制、当前诊断方式、针对不同患者特征的不断演变的管理策略以及导致治疗失败的复杂决定因素。通过剖析这些复杂方面，对GERD有了更深入的理解，为加强临床管理和改善患者预后铺平了道路。
