癌症中的转录因子FOXQ1

The transcription factor FOXQ1 in cancer.

作者信息

Koch Stefan

机构信息

Wallenberg Centre for Molecular Medicine (WCMM), Linköping University, Linköping, Sweden.

Department of Biomedical and Clinical Sciences (BKV), Linköping University, BKV/MMV - Plan 13, Lab 1, 581 85, Linköping, Sweden.

出版信息

Cancer Metastasis Rev. 2025 Jan 8;44(1):22. doi: 10.1007/s10555-025-10240-y.

DOI:10.1007/s10555-025-10240-y

PMID:39777582

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11711781/

Abstract

FOXQ1 is a member of the large forkhead box (FOX) family of transcription factors that is involved in all aspects of mammalian development, physiology, and pathobiology. FOXQ1 has emerged as a major regulator of epithelial-to-mesenchymal transition and tumour metastasis in cancers, especially carcinomas of the digestive tract. Accordingly, FOXQ1 induction is recognised as an independent prognostic factor for worse overall survival in several types of cancer, including gastric and colorectal cancer. In this review article, I summarise new evidence on the role of FOXQ1 in cancer, with a focus on molecular mechanisms that control FOXQ1 levels and the regulation of FOXQ1 target genes. Unravelling the functions of FOXQ1 has the potential to facilitate the development of targeted treatments for metastatic cancers.

摘要

FOXQ1是大型叉头框（FOX）转录因子家族的成员之一，参与哺乳动物发育、生理学和病理生物学的各个方面。FOXQ1已成为癌症尤其是消化道癌中上皮-间质转化和肿瘤转移的主要调节因子。因此，FOXQ1的诱导被认为是包括胃癌和结直肠癌在内的几种癌症总体生存率较差的独立预后因素。在这篇综述文章中，我总结了关于FOXQ1在癌症中作用的新证据，重点是控制FOXQ1水平的分子机制以及FOXQ1靶基因的调控。阐明FOXQ1的功能有可能促进转移性癌症靶向治疗的发展。