Omary Adam, Curtis Mark, Cheng Theresa W, Mair Patrick, Shirtcliff Elizabeth A, Barch Deanna M, Somerville Leah H
Department of Psychology and Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA.
Department of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, Missouri, USA.
Child Dev. 2025 May-Jun;96(3):980-999. doi: 10.1111/cdev.14220. Epub 2025 Jan 7.
Using data from the Human Connectome Project in Development (N = 1304; ages 5-21 years; 50% male; 59% White, 17% Hispanic, 13% Black, 9% Asian), multiple measures (self-report, salivary hormones) and research designs (longitudinal, cross-sectional) were used to characterize age-related changes and sex differences in pubertal development. Both sexes exhibit a sigmoid trajectory of pubertal development; females show earlier pubertal timing and increased tempo ~9-13 years, while males show greater tempo ~14-18 years. All hormones increased with age, with sex differences in testosterone and DHEA levels and in testosterone rates of change. Higher testosterone and DHEA corresponded with earlier pubertal timing in both sexes. These findings characterize typical pubertal and hormonal development and inform best practices for handling puberty data.
利用来自人类连接组发育项目的数据（N = 1304；年龄5至21岁；50%为男性；59%为白人，17%为西班牙裔，13%为黑人，9%为亚洲人），采用多种测量方法（自我报告、唾液激素）和研究设计（纵向、横断面）来描述青春期发育中与年龄相关的变化和性别差异。两性均呈现青春期发育的S形轨迹；女性在9至13岁左右青春期开始时间更早且发育速度加快，而男性在14至18岁左右发育速度更快。所有激素均随年龄增加，睾酮和脱氢表雄酮水平以及睾酮变化率存在性别差异。较高的睾酮和脱氢表雄酮水平与两性更早的青春期开始时间相对应。这些发现描绘了典型的青春期和激素发育情况，并为处理青春期数据的最佳实践提供了参考。
