儿童药物过量

Drug overdose in children.

作者信息

Tibballs J, McArdle E J, Brown T C

出版信息

Aust Paediatr J. 1985 Feb;21(1):7-11. doi: 10.1111/j.1440-1754.1985.tb00115.x.

DOI:10.1111/j.1440-1754.1985.tb00115.x

Abstract

This paper reviews epidemiological factors, drugs taken, management and outcome of 478 children admitted to the Royal Children's Hospital with drug poisoning during the 5 years 1978-82. Accidental ingestion in young children is still common whilst self poisoning is increasing in the age group 8-17 years. Suicide attempts and self destructive ingestion accounted for 11.5% of all cases with two deaths. A significant number in this group were less than 10 years of age. Iatrogenic poisoning accounted for 11% of all cases with metoclopramide or prochlorperazine frequently involved. Benzodiazepines, major tranquillizers and antihistamines were the most commonly taken groups of drugs whilst the greatest number of admissions to Intensive Care Unit were due to tricyclic poisoning. Principles of management are discussed.

摘要

本文回顾了1978年至1982年期间入住皇家儿童医院的478例药物中毒儿童的流行病学因素、所服用药物、治疗及预后情况。幼儿意外摄入药物仍很常见，而8至17岁年龄段的自我中毒情况呈上升趋势。自杀未遂及自我伤害性摄入占所有病例的11.5%，其中有两例死亡。该组中有相当一部分年龄小于10岁。医源性中毒占所有病例的11%，常涉及胃复安或氯丙嗪。苯二氮䓬类药物、强效镇静剂和抗组胺药是最常服用的几类药物，而重症监护病房收治人数最多的原因是三环类药物中毒。文中讨论了治疗原则。