Vo Anh Khoa, Crispo James A G, Liu Lisa J W, Thibault Dylan, Willis Allison W, Griesdale Donald E G, Kramer John L K, Cragg Jacquelyn J
Collaboration for Outcomes Research and Evaluation (CORE), Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada.
International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, British Columbia, Canada.
PLOS Glob Public Health. 2025 Jan 8;5(1):e0004022. doi: 10.1371/journal.pgph.0004022. eCollection 2025.
Complex regional pain syndrome is a chronic pain disorder marked by symptoms such as swelling, impaired motor function, and sympathetic dysfunction. Our primary objective was to determine the total number of complex regional pain syndrome type 1 (CRPS-1) emergency department (ED) visits and hospitalizations by race/ethnicity, as well as to assess sex and age distributions by race/ethnicity. Secondary objectives were to examine whether race/ethnicity, as well as select characteristics, are associated with hospitalization and longer length of stay. We completed a cross-sectional study of adults (19+ years) using acute and inpatient care data from the 2020 Nationwide Emergency Department Sample and the National Inpatient Sample. The overall rate of CRPS-1 diagnosis among ED visits and hospitalizations was 0.02% and 0.04%, respectively. Most CRPS-1 care was provided to White (ED: 83.1%; inpatient: 82.8%) patients. Within race/ethnicity groups, CRPS-1 ED visits and hospitalizations generally increased with age. Secondary findings included: 1) ED visits by Black individuals (compared with White) were significantly negatively associated with immediate hospitalization (adjusted odds ratio (AOR) 0.74, 95% CI 0.55 to 0.99); 2) hospitalizations by Black patients (compared with White) were independently associated with increased length of stay (odds ratio (OR) 1.45, 95% CI 1.07 to 1.96), though the association diminished with adjustment; and 3) drug abuse was significantly associated with hospitalization (AOR 4.67, 95% CI 3.53 to 6.18) and longer length of stay (AOR 1.81, 95% CI 1.34 to 2.46). Race/ethnicity was minimally associated with studied CRPS-1 outcomes. Additional studies are required to determine the impact of race/ethnicity on seeking care for CRPS-1.
复杂性区域疼痛综合征是一种慢性疼痛疾病，其特征为肿胀、运动功能受损和交感神经功能障碍等症状。我们的主要目标是确定按种族/族裔划分的1型复杂性区域疼痛综合征（CRPS-1）的急诊就诊和住院总数，并评估按种族/族裔划分的性别和年龄分布。次要目标是研究种族/族裔以及特定特征是否与住院和住院时间延长相关。我们利用2020年全国急诊样本和全国住院样本中的急性和住院护理数据，对成年人（19岁及以上）进行了一项横断面研究。急诊就诊和住院期间CRPS-1的总体诊断率分别为0.02%和0.04%。大多数CRPS-1护理提供给了白人患者（急诊：83.1%；住院：82.8%）。在种族/族裔群体中，CRPS-1的急诊就诊和住院人数一般随年龄增长而增加。次要发现包括：1）黑人个体的急诊就诊（与白人相比）与立即住院显著负相关（调整后的优势比（AOR）为0.74，95%置信区间为0.55至0.99）；2）黑人患者的住院（与白人相比）与住院时间延长独立相关（优势比（OR）为1.45，95%置信区间为1.07至1.96），不过这种关联在调整后有所减弱；3）药物滥用与住院（AOR为4.67，95%置信区间为3.53至6.18）和住院时间延长（AOR为1.81，95%置信区间为1.34至2.46）显著相关。种族/族裔与所研究的CRPS-1结局的关联极小。需要进一步研究以确定种族/族裔对CRPS-1就医的影响。
