Gang Roggers, Okello Denis, Ban Yeongjun, Kang Youngmin
Korean Convergence Medical Science Major, Korea National University of Science and Technology (UST), Daejeon 34113, South Korea; Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine (KIOM), 111 Geonjae-Ro, Naju-Si, South Korea; National Agricultural Research Organization (NARO), National Semi-Arid Resources Research Institute (NaSARRI), Soroti, Uganda.
Department of Biological Sciences, Kabale University, PO Box 317, Kabale, Uganda.
Pharmacol Res. 2025 Feb;212:107590. doi: 10.1016/j.phrs.2025.107590. Epub 2025 Jan 6.
Aspilia africana (Pers.) C. D. Adams, popularly referred to as wild sunflower, has been used for generations across several African communities to treat various diseases, including malaria, wounds, osteoporosis, diabetes mellitus, gastric ulcers, measles, tuberculosis, stomach ache, rheumatic pains, and gonorrhea. This study aimed to systematically and critically compile data on the traditional medicinal uses, phytochemistry, bioactivities, botanical descriptions, and toxicities of A. africana. Relevant research findings were retrieved and organized from various databases, including PubMed and ScienceDirect, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. To date, 149 phytochemicals have been identified from various A. africana parts and they primarily belong to the classes of terpenoids, lipids, hydrocarbons, phenolics, and esters. The extracts and bioactive phytochemicals of A. africana have revealed several pharmacological properties, including antimalarial, anticancer, wound healing, anti-inflammatory, antidiabetic, and antimicrobial activities. However, the major components responsible for these bioactivities and their mechanisms of action in some diseases have not yet been clearly identified. Additionally, toxicity and clinical trial data for A. africana are limited with most toxicological assessments being acute in nature. Therefore, further research on the mechanisms of action of the pure bioactive phytochemicals and toxicity of A. africana are necessary to better understand its efficacy and safety. Taken together, this study provides comprehensive information on the traditional medicinal uses, phytochemistry, bioactivities, and toxicity of A. africana, and a reference for future studies, relevant to the development of therapeutic products.
非洲紫菀（Aspilia africana (Pers.) C. D. Adams），俗称野生向日葵，在非洲多个社区已被世代用于治疗各种疾病，包括疟疾、伤口、骨质疏松症、糖尿病、胃溃疡、麻疹、肺结核、胃痛、风湿痛和淋病。本研究旨在系统且批判性地汇编关于非洲紫菀的传统药用、植物化学、生物活性、植物描述和毒性的数据。根据系统评价和荟萃分析的首选报告项目指南，从包括PubMed和ScienceDirect在内的各种数据库中检索并整理了相关研究结果。迄今为止，已从非洲紫菀的各个部位鉴定出149种植物化学物质，它们主要属于萜类、脂质、烃类、酚类和酯类。非洲紫菀的提取物和具有生物活性的植物化学物质已显示出多种药理特性，包括抗疟疾、抗癌、伤口愈合、抗炎、抗糖尿病和抗菌活性。然而，导致这些生物活性的主要成分及其在某些疾病中的作用机制尚未明确确定。此外，非洲紫菀的毒性和临床试验数据有限，大多数毒理学评估都是急性性质的。因此，有必要进一步研究纯生物活性植物化学物质的作用机制和非洲紫菀的毒性，以更好地了解其疗效和安全性。综上所述，本研究提供了关于非洲紫菀的传统药用、植物化学、生物活性和毒性的全面信息，并为与治疗产品开发相关的未来研究提供了参考。
