Kesner Adam L, Brosch-Lenz Julia, Gear Jonathan, Lassmann Michael
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York.
Institute of Nuclear Medicine, Glen Burnie, Maryland.
J Nucl Med. 2025 Feb 3;66(2):166-172. doi: 10.2967/jnumed.124.268998.
Dosimetry is integral to informed implementation of radiopharmaceutical therapies, enabling personalized treatment planning and ensuring patient safety by calculating absorbed doses to organs and tumors. As the therapeutic radiopharmaceutical field continues to expand, dosimetry software has emerged as a crucial tool for optimization of treatment efficacy. This review discusses key features and capabilities that current dosimetry software solutions have or should have in the future. We highlight the need for standardization across platforms to support consistent and accurate dose calculations. Furthermore, we explore opportunities for advancing software, such as incorporating biologically effective dose modeling and improving uncertainty quantification. Looking ahead, we advocate for expanding infrastructure for open data sets and fostering ongoing collaboration between vendors and end users to guide the field toward greater integration and efficacy.
剂量测定对于放射性药物治疗的明智实施至关重要，它通过计算器官和肿瘤的吸收剂量来实现个性化治疗规划并确保患者安全。随着治疗性放射性药物领域的不断扩展，剂量测定软件已成为优化治疗效果的关键工具。本综述讨论了当前剂量测定软件解决方案现有的或未来应具备的关键特性和功能。我们强调跨平台标准化的必要性，以支持一致且准确的剂量计算。此外，我们探索软件改进的机会，例如纳入生物有效剂量建模和改进不确定性量化。展望未来，我们主张扩展开放数据集的基础设施，并促进供应商与终端用户之间的持续合作，以引导该领域实现更大程度的整合与更高的效能。
