Dahl A R, Brezinski D A
Biochem Pharmacol. 1985 Mar 1;34(5):631-6. doi: 10.1016/0006-2952(85)90256-4.
Eighteen methylenedioxyphenyl (MDP) compounds, including some commonly inhaled by people, were tested for the ability to inhibit rabbit nasal microsomal cytochrome P-450-dependent hexamethylphosphoramide (HMPA) N-demethylase. For comparison, liver microsomes were also used. Nasal cytochrome P-450 from rabbits metabolized MDP compounds to form cytochrome P-450-metabolite (P-450-MI) complexes as indicated by difference spectra in the Soret region. Several of the MDP compounds were potent inhibitors of nasal P-450-dependent N-demethylase. If inhibition of nasal P-450 also occurs in vivo after inhibiting MDP compounds are inhaled, the metabolism of concurrently or subsequently inhaled compounds may be altered.
对18种亚甲二氧基苯基（MDP）化合物进行了测试，其中包括一些人们常用作吸入剂的化合物，以检测它们抑制兔鼻微粒体细胞色素P - 450依赖性六甲基磷酰胺（HMPA）N - 脱甲基酶的能力。作为对照，也使用了肝微粒体。兔鼻细胞色素P - 450将MDP化合物代谢形成细胞色素P - 450 - 代谢物（P - 450 - MI）复合物，这可通过Soret区域的差光谱来表明。几种MDP化合物是鼻P - 450依赖性N - 脱甲基酶的有效抑制剂。如果吸入抑制性MDP化合物后在体内也发生鼻P - 450的抑制，那么同时或随后吸入的化合物的代谢可能会改变。
