Chen Xiao, Li Yaqi, Shen Yun, Schwarzschild Michael A, Gao Xiang
Department of Nutrition and Food Hygiene, School of Public Health, Institute of Nutrition, Zhongshan Hospital, Fudan University, Shanghai, China.
Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
NPJ Parkinsons Dis. 2025 Jan 9;11(1):14. doi: 10.1038/s41531-024-00863-3.
Association of prodromal Parkinson's disease (PD) with risk of PD and risk of mortality in individuals with PD warrant investigation through large-scale prospective study. We included 501,475 participants without PD at baseline. Eight prodromal features were measured. Incident PD cases were identified via hospital admission, death register, and self-report. Cox regression models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs). Multivariable-adjusted HRs and 95%CIs were 3.12 (2.58-3.78) for men and 2.71 (2.11-3.47) for women. Prodromal PD predicted only PD onset occurred during the first 6 years of follow-up (HR = 10.5; 95% CI: 8.60-12.9), but not after 6 years (HR = 1.00; 95%CI: 0.76-1.32). The presence of prodromal PD conferred a higher risk of mortality among participants with PD. Having prodromal PD were associated with higher probability of developing PD in short-term and higher risk of mortality among individuals with PD.
前驱帕金森病（PD）与PD风险及PD患者死亡率之间的关联值得通过大规模前瞻性研究进行调查。我们纳入了501475名基线时无PD的参与者。测量了8个前驱特征。通过医院入院记录、死亡登记和自我报告确定新发PD病例。使用Cox回归模型计算风险比（HR）和95%置信区间（CI）。多变量调整后的HR和95%CI男性为3.12（2.58 - 3.78），女性为2.71（2.11 - 3.47）。前驱PD仅预测在随访的前6年发生PD发病（HR = 10.5；95%CI：8.60 - 12.9），但6年后则不然（HR = 1.00；95%CI：0.76 - 1.32）。前驱PD的存在使PD患者的死亡风险更高。患有前驱PD与短期内发生PD的较高概率以及PD患者较高的死亡风险相关。
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