Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.
Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Mov Disord. 2022 Dec;37(12):2367-2375. doi: 10.1002/mds.29208. Epub 2022 Sep 7.
The prodromal phase of Parkinson's disease (PD) is a critical window for prevention by modifying lifestyle factors. However, there is limited knowledge on how diet quality is associated with prodromal PD symptoms in Asian populations.
To examine the association between overall diet quality and prodromal PD features.
A total of 71,640 Chinese participants who were free of PD were included in this cross-sectional study. Diet quality was assessed using the modified Alternative Healthy Eating Index (mAHEI) and alternate Mediterranean Diet (aMED). Five prodromal features including probable rapid eye movement sleep behavior disorder (pRBD), hyposmia, excessive daytime sleepiness, constipation, and depressive symptom were measured using validated questionnaires. Logistic regression was used to calculate the odds ratio (OR) for having a combination of prodromal PD symptoms (1 and 2+ symptoms vs. 0 symptoms), adjusting for age, sex, lifestyle factors, total energy intake, and other potential confounders.
In the multivariable-adjusted model, the OR for having 2+ versus 0 prodromal PD features was 0.64 (95% confidence interval [CI]: 0.49, 0.85) comparing the highest versus the lowest mAHEI diet quality quartiles with a significant inverse trend (P-trend = 0.003). For individual prodromal PD features, better diet quality, as assessed by the mAHEI, was associated with lower odds of having excessive daytime sleepiness and constipation (P-trend < 0.05 for both). We observed a marginally significant association between aMED and prodromal PD features (adjusted OR comparing the extreme quartiles = 0.74; 95% CI: 0.55, 0.98; P-trend = 0.09).
Better diet quality, as assessed by the mAHEI and the aMED, was associated with lower probability of having prodromal PD features in Chinese adults. © 2022 International Parkinson and Movement Disorder Society.
帕金森病（PD）的前驱期是通过改变生活方式因素进行预防的关键窗口。然而，关于亚洲人群的饮食质量如何与前驱期 PD 症状相关，我们知之甚少。
研究整体饮食质量与前驱期 PD 特征之间的关系。
本横断面研究共纳入 71640 名无 PD 的中国参与者。使用改良替代健康饮食指数（mAHEI）和替代地中海饮食（aMED）评估饮食质量。使用经过验证的问卷测量五种前驱期特征，包括可能的快速眼动睡眠行为障碍（pRBD）、嗅觉减退、日间过度嗜睡、便秘和抑郁症状。使用逻辑回归计算具有前驱期 PD 症状（1 个和 2+个症状与 0 个症状）组合的比值比（OR），调整年龄、性别、生活方式因素、总能量摄入和其他潜在混杂因素。
在多变量调整模型中，与最低 mAHEI 饮食质量四分位数相比，最高四分位数的 2+个与 0 个前驱期 PD 特征的 OR 为 0.64（95%置信区间[CI]：0.49，0.85），呈显著负相关趋势（P 趋势=0.003）。对于个体前驱期 PD 特征，mAHEI 评估的更好的饮食质量与日间过度嗜睡和便秘的可能性较低相关（两者的 P 趋势均<0.05）。我们观察到 aMED 与前驱期 PD 特征之间存在边缘显著的关联（极端四分位数之间的调整 OR=0.74；95%CI：0.55，0.98；P 趋势=0.09）。
mAHEI 和 aMED 评估的更好的饮食质量与中国成年人前驱期 PD 特征的可能性较低相关。© 2022 国际帕金森病和运动障碍学会。
