Yamamoto Yasunori, Furukawa Shinya, Yoshida Osamu, Miyake Teruki, Shiraishi Kana, Hashimoto Yu, Tange Kazuhiro, Kitahata Shogo, Ninomiya Tomoyuki, Yagi Sen, Masakazu Hanayama, Suzuki Seiyuu, Shibata Naozumi, Murakami Hidehiro, Ohashi Katsuhisa, Tomida Hideomi, Takeshita Eiji, Ikeda Yoshio, Hiasa Yoichi
Endoscopy Center, Ehime University Hospital, Toon, Ehime, Japan.
Health Services Center, Ehime University, Matsuyama, Ehime, 790-8577, Japan.
Sci Rep. 2025 Jan 8;15(1):1272. doi: 10.1038/s41598-025-85916-0.
Allergic diseases and ulcerative colitis (UC) share pathophysiological similarities. This study aimed to investigate the unclear association between allergic diseases and mucosal healing (MH), an important factor in the prognosis of UC. We studied 289 Japanese patients with UC. Information on allergic diseases (bronchial asthma, atopic dermatitis, pollen allergy, food allergy, and drug allergy), as diagnosed by physicians, was collected through self-reported questionnaires. The definition of MH was Mayo Endoscopic Score 0. The association between each allergic disease and its multimorbidity with MH was evaluated using multivariate logistic regression analyses. Pollen allergy was the most common allergic condition (36.3%). Pollen allergy and food allergy were independently associated with MH (pollen allergy adjusted OR: 1.82 [95% CI: 1.01-3.26]; food allergy adjusted OR: 3.47 [95% CI: 1.26-9.68]). The rates of MH for 0 and 3 or more allergic diseases were 24.6% and 4.2%, respectively. After adjustment for confounders, 3 or more allergic diseases were independently associated with MH (adjusted OR: 8.13 [95% CI: 2.17-34.04], p for trend = 0.020). This study demonstrates a significant positive association between specific allergic diseases (pollen and food allergies) and MH in UC patients, with a stronger association in cases of allergic multimorbidity.
过敏性疾病与溃疡性结肠炎（UC）在病理生理学上具有相似性。本研究旨在探讨过敏性疾病与黏膜愈合（MH）之间尚不明确的关联，黏膜愈合是UC预后的一个重要因素。我们研究了289例日本UC患者。通过自我报告问卷收集了由医生诊断的过敏性疾病（支气管哮喘、特应性皮炎、花粉过敏、食物过敏和药物过敏）信息。MH的定义为梅奥内镜评分0分。使用多因素逻辑回归分析评估每种过敏性疾病及其合并多种过敏疾病与MH之间的关联。花粉过敏是最常见的过敏情况（36.3%）。花粉过敏和食物过敏与MH独立相关（花粉过敏校正比值比：1.82 [95%可信区间：1.01 - 3.26]；食物过敏校正比值比：3.47 [95%可信区间：1.26 - 9.68]）。0种和3种或更多种过敏性疾病的MH发生率分别为24.6%和4.2%。在对混杂因素进行校正后，3种或更多种过敏性疾病与MH独立相关（校正比值比：8.13 [95%可信区间：2.17 - 34.04]，趋势检验p = 0.020）。本研究表明，UC患者中特定的过敏性疾病（花粉和食物过敏）与MH之间存在显著的正相关，在合并多种过敏疾病的情况下相关性更强。
