Yamamoto Yasunori, Furukawa Shinya, Miyake Teruki, Watanabe Junichi, Nakamura Yukihiro, Taguchi Yoshihiro, Yamamoto Tetsuya, Kato Aki, Kusumoto Katsunori, Yoshida Osamu, Takeshita Eiji, Ikeda Yoshio, Yamamoto Naofumi, Saeki Yuka, Yamaguchi Osamu, Hiasa Yoichi
Endoscopy Center, Ehime University Hospital, Toon, Ehime, Japan.
Health Services Center, Ehime University, Matsuyama, Ehime, Japan.
J Neurogastroenterol Motil. 2024 Apr 30;30(2):229-235. doi: 10.5056/jnm23015.
BACKGROUND/AIMS: Although certain allergic diseases have been reported to be associated with the prevalence of functional dyspepsia (FD) and irritable bowel syndrome (IBS), it is unclear whether the presence of multiple allergic diseases further increases the prevalence of FD and IBS. The aim of this study is to determine this issue in young people.
A cohort of 8923 Japanese university students was enrolled and diagnoses of FD and IBS were confirmed using Rome III criteria. Allergic disorders diagnosed at medical institutions were obtained by means of a self-administered questionnaire.
The prevalence of FD, IBS, and their overlap was found to be 1.9%, 6.5%, and 1.1%, respectively. Pollen allergy was independently positively correlated with FD, IBS, and overlap of FD and IBS. Allergic rhinitis was positively linked to IBS. Drug allergy was positively associated with FD. The presence of multiple allergic diseases was positively correlated with FD and IBS (FD: adjusted OR for 2 allergic diseases: 1.95 [95% CI, 1.24-2.98], for trend = 0.003; and IBS: adjusted OR for 1 allergic disease: 1.40 [95% CI, 1.15-1.69], 2 allergic diseases 1.47 [95% CI, 1.12-1.91], and 3 or more allergic diseases: 2.22 [95% CI, 1.45-3.28], for trend = 0.001). Additionally, the concomitant existence of multiple allergic diseases was also demonstrated to have a trend that correlated with the overlap of FD and IBS ( for trend = 0.018).
Allergic disease multimorbidity is positively correlated with the prevalence of FD and IBS in a young population.
背景/目的：尽管已有报道称某些过敏性疾病与功能性消化不良（FD）和肠易激综合征（IBS）的患病率相关，但尚不清楚多种过敏性疾病的存在是否会进一步增加FD和IBS的患病率。本研究旨在确定年轻人中的这一问题。
招募了8923名日本大学生队列，并使用罗马III标准确诊FD和IBS。通过自填问卷获取在医疗机构诊断出的过敏性疾病。
发现FD、IBS及其重叠情况的患病率分别为1.9%、6.5%和1.1%。花粉过敏与FD、IBS以及FD和IBS的重叠独立正相关。过敏性鼻炎与IBS正相关。药物过敏与FD正相关。多种过敏性疾病的存在与FD和IBS正相关（FD：2种过敏性疾病的校正比值比：1.95[95%置信区间，1.24 - 2.98]，趋势P值 = 0.003；IBS：1种过敏性疾病的校正比值比：1.40[95%置信区间，1.15 - 1.69]，2种过敏性疾病1.47[95%置信区间，1.12 - 1.91]，3种或更多过敏性疾病：2.22[95%置信区间，1.45 - 3.28]，趋势P值 = 0.001）。此外，还证明多种过敏性疾病的并存也有与FD和IBS重叠相关的趋势（趋势P值 = 0.018）。
在年轻人群中，过敏性疾病共病与FD和IBS的患病率正相关。
