Zhou Feifan, Xu Yuanze, Liu Xing, Xu Yan, Wang Yan, Jiang Donghui, Du Pengfei
Department of Critical Care Medicine, Affiliated Hospital of Jiangnan University, Wuxi, China.
The Second Clinical College, Zhejiang Chinese Medical University, Hangzhou, China.
Rev Med Virol. 2025 Jan;35(1):e70014. doi: 10.1002/rmv.70014.
Zika virus (ZIKV) and dengue virus (DENV) are two major mosquito-borne flaviviruses that pose a significant threat to the global public health system, particularly in tropical regions. The clinical outcomes related to these viral pathogens can vary from self-limiting asymptomatic infections to various forms of life-threatening pathological conditions such as haemorrhagic disorders. In addition to the direct effects of the viral pathogens, immune processes play also a significant function in the development of diseases mediated by ZIKV and DENV. Studing these processes is important for developing safer vaccines and targeted therapeutic strategies. These viruses have been reported to trigger various autoimmune disorders affecting different parts of human organ systems. It also has been shown that preexisting immunity to ZIKV or DENV can impact the outcome of subsequent infections caused by another virus. ZIKV and DENV infection can promote the development of autoimmune disorders by different mechanisms, such as molecular mimicry and autoantibody formation. The present review provides an overview of various autoimmune disorders associated with ZIKV and DENV infection and their potential underlying mechanisms.
寨卡病毒（ZIKV）和登革病毒（DENV）是两种主要的蚊媒黄病毒，对全球公共卫生系统构成重大威胁，尤其是在热带地区。与这些病毒病原体相关的临床结果可能从自限性无症状感染到各种危及生命的病理状况，如出血性疾病。除了病毒病原体的直接影响外，免疫过程在由寨卡病毒和登革病毒介导的疾病发展中也起着重要作用。研究这些过程对于开发更安全的疫苗和靶向治疗策略很重要。据报道，这些病毒会引发影响人体器官系统不同部位的各种自身免疫性疾病。研究还表明，对寨卡病毒或登革病毒的预先存在的免疫力会影响由另一种病毒引起的后续感染的结果。寨卡病毒和登革病毒感染可通过不同机制促进自身免疫性疾病的发展，如分子模拟和自身抗体形成。本综述概述了与寨卡病毒和登革病毒感染相关的各种自身免疫性疾病及其潜在的潜在机制。
