回复：氨基酸和KLHL22不会通过DEPDC5降解激活mTORC1。 - Suppr

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Reply to: Amino acids and KLHL22 do not activate mTORC1 via DEPDC5 degradation.

作者信息

Chen Jie, Ou Yuhui, Liu Ying

机构信息

Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing, China.

School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.

出版信息

Nature. 2025 Jan;637(8045):E15-E17. doi: 10.1038/s41586-024-07975-z.

DOI:10.1038/s41586-024-07975-z

PMID:39780003

Abstract

摘要

相似文献

Reply to: Amino acids and KLHL22 do not activate mTORC1 via DEPDC5 degradation.

Nature. 2025 Jan;637(8045):E15-E17. doi: 10.1038/s41586-024-07975-z.

Amino acids and KLHL22 do not activate mTORC1 via DEPDC5 degradation.

Nature. 2025 Jan;637(8045):E11-E14. doi: 10.1038/s41586-024-07974-0. Epub 2025 Jan 8.

KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing.

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Persistent mTORC1 activation via Depdc5 deletion results in spontaneous hepatocellular carcinoma but does not exacerbate carcinogen- and high-fat diet-induced hepatic carcinogenesis in mice.

Biochem Biophys Res Commun. 2021 Nov 12;578:142-149. doi: 10.1016/j.bbrc.2021.09.036. Epub 2021 Sep 20.

Phosphorylation of DEPDC5, a component of the GATOR1 complex, releases inhibition of mTORC1 and promotes tumor growth.

Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20505-20510. doi: 10.1073/pnas.1904774116. Epub 2019 Sep 23.

Depdc5 deficiency exacerbates alcohol-induced hepatic steatosis via suppression of PPARα pathway.

Cell Death Dis. 2021 Jul 15;12(7):710. doi: 10.1038/s41419-021-03980-6.

Skeletal muscle-specific knockout of DEP domain containing 5 protein increases mTORC1 signaling, muscle cell hypertrophy, and mitochondrial respiration.

J Biol Chem. 2019 Mar 15;294(11):4091-4102. doi: 10.1074/jbc.RA118.005970. Epub 2019 Jan 11.

DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting.

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Adipocyte-specific deletion of Depdc5 exacerbates insulin resistance and adipose tissue inflammation in mice.

Biochem Biophys Res Commun. 2021 Sep 10;569:118-124. doi: 10.1016/j.bbrc.2021.07.003. Epub 2021 Jul 7.

DEPDC5 and NPRL3 modulate cell size, filopodial outgrowth, and localization of mTOR in neural progenitor cells and neurons.

Neurobiol Dis. 2018 Jun;114:184-193. doi: 10.1016/j.nbd.2018.02.013. Epub 2018 Feb 24.

本文引用的文献

Structural mechanisms for regulation of GSDMB pore-forming activity.

Nature. 2023 Apr;616(7957):598-605. doi: 10.1038/s41586-023-05872-5. Epub 2023 Mar 29.

Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells.

Cell Death Differ. 2023 May;30(5):1366-1381. doi: 10.1038/s41418-023-01143-y. Epub 2023 Mar 11.

Ring domains are essential for GATOR2-dependent mTORC1 activation.

Mol Cell. 2023 Jan 5;83(1):74-89.e9. doi: 10.1016/j.molcel.2022.11.021. Epub 2022 Dec 16.

USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction.

Cell Rep. 2022 Dec 6;41(10):111653. doi: 10.1016/j.celrep.2022.111653.

Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development.

Development. 2022 Dec 15;149(24). doi: 10.1242/dev.201286. Epub 2022 Dec 20.

Depdc5 deficiency exacerbates alcohol-induced hepatic steatosis via suppression of PPARα pathway.

Cell Death Dis. 2021 Jul 15;12(7):710. doi: 10.1038/s41419-021-03980-6.

Genomic Alterations in -Mutated Breast Cancer Result in mTORC1 Activation and Limit the Sensitivity to PI3Kα Inhibitors.

Cancer Res. 2021 May 1;81(9):2470-2480. doi: 10.1158/0008-5472.CAN-20-3232. Epub 2021 Mar 8.

Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity.

Mol Cell. 2020 Nov 5;80(3):437-451.e6. doi: 10.1016/j.molcel.2020.10.004.

Phosphorylation of DEPDC5, a component of the GATOR1 complex, releases inhibition of mTORC1 and promotes tumor growth.

Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20505-20510. doi: 10.1073/pnas.1904774116. Epub 2019 Sep 23.

KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing.

Nature. 2018 May;557(7706):585-589. doi: 10.1038/s41586-018-0128-9. Epub 2018 May 16.

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Reply to: Amino acids and KLHL22 do not activate mTORC1 via DEPDC5 degradation.

作者信息

Chen Jie, Ou Yuhui, Liu Ying

机构信息

Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing, China.

School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.

出版信息

Nature. 2025 Jan;637(8045):E15-E17. doi: 10.1038/s41586-024-07975-z.

DOI:10.1038/s41586-024-07975-z

PMID:39780003

Abstract

摘要

相似文献

Reply to: Amino acids and KLHL22 do not activate mTORC1 via DEPDC5 degradation.

Nature. 2025 Jan;637(8045):E15-E17. doi: 10.1038/s41586-024-07975-z.

Amino acids and KLHL22 do not activate mTORC1 via DEPDC5 degradation.

Nature. 2025 Jan;637(8045):E11-E14. doi: 10.1038/s41586-024-07974-0. Epub 2025 Jan 8.

KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing.

Nature. 2018 May;557(7706):585-589. doi: 10.1038/s41586-018-0128-9. Epub 2018 May 16.

Persistent mTORC1 activation via Depdc5 deletion results in spontaneous hepatocellular carcinoma but does not exacerbate carcinogen- and high-fat diet-induced hepatic carcinogenesis in mice.

Biochem Biophys Res Commun. 2021 Nov 12;578:142-149. doi: 10.1016/j.bbrc.2021.09.036. Epub 2021 Sep 20.

Phosphorylation of DEPDC5, a component of the GATOR1 complex, releases inhibition of mTORC1 and promotes tumor growth.

Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20505-20510. doi: 10.1073/pnas.1904774116. Epub 2019 Sep 23.

Depdc5 deficiency exacerbates alcohol-induced hepatic steatosis via suppression of PPARα pathway.

Cell Death Dis. 2021 Jul 15;12(7):710. doi: 10.1038/s41419-021-03980-6.

Skeletal muscle-specific knockout of DEP domain containing 5 protein increases mTORC1 signaling, muscle cell hypertrophy, and mitochondrial respiration.

J Biol Chem. 2019 Mar 15;294(11):4091-4102. doi: 10.1074/jbc.RA118.005970. Epub 2019 Jan 11.

DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting.

Cell Rep. 2022 Aug 30;40(9):111278. doi: 10.1016/j.celrep.2022.111278.

Adipocyte-specific deletion of Depdc5 exacerbates insulin resistance and adipose tissue inflammation in mice.

Biochem Biophys Res Commun. 2021 Sep 10;569:118-124. doi: 10.1016/j.bbrc.2021.07.003. Epub 2021 Jul 7.

DEPDC5 and NPRL3 modulate cell size, filopodial outgrowth, and localization of mTOR in neural progenitor cells and neurons.

Neurobiol Dis. 2018 Jun;114:184-193. doi: 10.1016/j.nbd.2018.02.013. Epub 2018 Feb 24.

本文引用的文献

Structural mechanisms for regulation of GSDMB pore-forming activity.

Nature. 2023 Apr;616(7957):598-605. doi: 10.1038/s41586-023-05872-5. Epub 2023 Mar 29.

Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells.

Cell Death Differ. 2023 May;30(5):1366-1381. doi: 10.1038/s41418-023-01143-y. Epub 2023 Mar 11.

Ring domains are essential for GATOR2-dependent mTORC1 activation.

Mol Cell. 2023 Jan 5;83(1):74-89.e9. doi: 10.1016/j.molcel.2022.11.021. Epub 2022 Dec 16.

USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction.

Cell Rep. 2022 Dec 6;41(10):111653. doi: 10.1016/j.celrep.2022.111653.

Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development.

Development. 2022 Dec 15;149(24). doi: 10.1242/dev.201286. Epub 2022 Dec 20.

Depdc5 deficiency exacerbates alcohol-induced hepatic steatosis via suppression of PPARα pathway.

Cell Death Dis. 2021 Jul 15;12(7):710. doi: 10.1038/s41419-021-03980-6.

Genomic Alterations in -Mutated Breast Cancer Result in mTORC1 Activation and Limit the Sensitivity to PI3Kα Inhibitors.

Cancer Res. 2021 May 1;81(9):2470-2480. doi: 10.1158/0008-5472.CAN-20-3232. Epub 2021 Mar 8.

Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity.

Mol Cell. 2020 Nov 5;80(3):437-451.e6. doi: 10.1016/j.molcel.2020.10.004.

Phosphorylation of DEPDC5, a component of the GATOR1 complex, releases inhibition of mTORC1 and promotes tumor growth.

Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20505-20510. doi: 10.1073/pnas.1904774116. Epub 2019 Sep 23.

KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing.

Nature. 2018 May;557(7706):585-589. doi: 10.1038/s41586-018-0128-9. Epub 2018 May 16.