Yu Xinping, Zheng Heqing, Liu Mingxu, Wu Lanxiang, Tian Sheng, Wu Wei
Department of Neurology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People's Republic of China.
Institute of Neuroscience, Nanchang University, Nanchang, 330006, People's Republic of China.
BMC Psychiatry. 2025 Jan 8;25(1):25. doi: 10.1186/s12888-024-06463-y.
The relationship between the systemic immune-inflammatory index (SII) and the mortality of adults with depression is uncertain.
This study included adults with depression who were surveyed in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. Cox proportional hazards regression models to compute hazard ratios (HR) and 95% confidence intervals (CI) for mortality.The restricted cubic spline(RCS), Kaplan-Meier curve analysis, time-dependent ROC analysis, subgroup and sensitivity analyses were also used.
A total of 2442 adults with depression were included in the final analysis(average age: 46.51 ± 0.44 years). During a median follow-up of 89 months, there were 302 all-cause deaths and 74 cardiovascular deaths. The fully adjusted model showed that an increment of 100 unit in SII corresponded to an increased HR of 1.05(95% CI,1.02,1.08, p = 0.003) for all-cause mortality and 1.06(95% CI,1.02,1.10, p = 0.004) for cardiovascular mortality, respectively. The RCS analysis indicated a J-shape relationship between SII and all-cause mortality and a positive linear association between SII and cardiovascular mortality.The time-dependent ROC analysis exhibited excellent efficacy in SII for predicting all-cause and cardiovascular mortality at 1, 3, 5 and 10 years.
Higher SII levels were associated with increased risk of all-cause and cardiovascular mortality in adults with depression.
Not applicable.
全身免疫炎症指数（SII）与抑郁症成年患者死亡率之间的关系尚不确定。
本研究纳入了2005年至2018年在美国国家健康与营养检查调查（NHANES）中接受调查的抑郁症成年患者。采用Cox比例风险回归模型计算死亡率的风险比（HR）和95%置信区间（CI）。还使用了受限立方样条（RCS）、Kaplan-Meier曲线分析、时间依赖性ROC分析、亚组分析和敏感性分析。
最终分析共纳入2442例抑郁症成年患者（平均年龄：46.51±0.44岁）。在中位随访89个月期间，共有302例全因死亡和74例心血管死亡。完全调整模型显示，SII每增加100个单位，全因死亡率的HR增加1.05（95%CI，1.02，1.08，p = 0.003），心血管死亡率的HR增加1.06（95%CI，1.02，1.10，p = 0.004）。RCS分析表明SII与全因死亡率之间呈J形关系，SII与心血管死亡率之间呈正线性关系。时间依赖性ROC分析显示SII在预测1年、3年、5年和10年的全因和心血管死亡率方面具有优异的效能。
抑郁症成年患者中较高的SII水平与全因和心血管死亡风险增加相关。
不适用。
