年轻高血压患者的左心室肥厚：mTOR与血管紧张素II之间可能的相互作用——一项病例对照研究

Left ventricular hypertrophy in young hypertensives: the possible crosstalk of mTOR and angiotensin-II -a case-control study.

作者信息

Oguntola Busayo Onafowoke, Oguntola Stephen Olawale, Ojo Opeyemi Ezekiel, Ukpabio Pauleen Ayomide, Omoaghe Adams Olalekan, Olaniyi Kehinde Samuel

机构信息

Department of Internal Medicine, ABUAD Multisystem Hospital, Afe Babalola University, Ado- Ekiti, 360101, Nigeria.

Cardio/Endo-metabolic and Microbiome Research Unit, Department of Physiology, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, 360101, Nigeria.

出版信息

BMC Cardiovasc Disord. 2025 Jan 9;25(1):9. doi: 10.1186/s12872-025-04470-9.

DOI:10.1186/s12872-025-04470-9

PMID:39780084

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11714912/

Abstract

BACKGROUND

Hypertension is a major cause of cardiac dysfunction. The earliest manifestation is left ventricular remodeling/hypertrophy. The occurrence of adverse cardiac remodeling and outcomes occurs irrespective of age in blacks. This necessitated an estimate of the prevalence of left ventricular hypertrophy (LVH) and an assessment of the roles of the mammalian target organ of rapamycin (mTOR) and angiotensin-II (Ang II) as possible pathogenic markers of LVH among young hypertensives.

METHODS

This prospective case-control study involved 110 hypertensive and 60 normotensive (control) participants aged 18-45 across tertiary hospitals in Ekiti state. Ethical approval was obtained from all the various institutions. Participants were recruited consecutively after giving informed consent. Sociodemographic/clinical information, resting electrocardiogram and echocardiography were obtained. Venous blood was obtained to estimate mTOR, Ang II, Chemerin, lipids - triglyceride (TG), high-density lipoprotein (HDL), total cholesterol (TC), troponin-T, NF-Kβ, and Galectin-3 using enzyme-linked immunosorbent assay.

RESULTS

The prevalence of LVH among the hypertensive group was 20.9%, 39%, 11.01%, and 15.74% using 2D-transthoracic echocardiography, Sokolow-Lyon, Cornell's and Cornell product ECG criteria. Also, hypertensives with LVH had a significantly increased blood pressure, body mass index, serum level of TG, TG/HDL, TC/HDL, chemerin, troponin T, Galectin-3 and total mTOR compared to normotensive and hypertensives without LVH. At the same time, serum NF-kβ and Ang II were only significant when compared with normotensive but not hypertensives without LVH. The total mTOR moderately correlated positively with ANG-II.

CONCLUSIONS

The results suggest an interaction between mTOR and Ang II in the development of LVH. In addition, it shows that LVH is associated with dyslipidemia, inflammation, and fibrosis.

摘要

背景

高血压是心脏功能障碍的主要原因。最早的表现是左心室重塑/肥厚。黑人无论年龄大小都会出现不良心脏重塑和后果。这就需要估计左心室肥厚（LVH）的患病率，并评估雷帕霉素的哺乳动物靶器官（mTOR）和血管紧张素II（Ang II）作为年轻高血压患者LVH可能的致病标志物的作用。

方法

这项前瞻性病例对照研究涉及埃基蒂州各三级医院的110名高血压患者和60名血压正常（对照）参与者，年龄在18至45岁之间。获得了所有不同机构的伦理批准。参与者在签署知情同意书后连续招募。获取社会人口统计学/临床信息、静息心电图和超声心动图。采集静脉血，使用酶联免疫吸附测定法估计mTOR、Ang II、卡莫林、血脂 - 甘油三酯（TG）、高密度脂蛋白（HDL）、总胆固醇（TC）、肌钙蛋白T、NF-Kβ和半乳糖凝集素-3。

结果

使用二维经胸超声心动图、索科洛 - 里昂、康奈尔和康奈尔乘积心电图标准，高血压组中LVH的患病率分别为20.9%、39%、11.01%和15.74%。此外，与血压正常者和无LVH的高血压患者相比，有LVH的高血压患者的血压、体重指数、血清TG水平、TG/HDL、TC/HDL、卡莫林、肌钙蛋白T、半乳糖凝集素-3和总mTOR显著升高。同时，血清NF-kβ和Ang II仅在与血压正常者相比时有显著差异，与无LVH的高血压患者相比无显著差异。总mTOR与ANG-II呈中度正相关。