褪黑素对卵巢储备功能减退女性卵泡氧化应激及辅助生殖结局的影响：一项随机对照试验
The effects of melatonin on follicular oxidative stress and art outcomes in women with diminished ovarian reserve: a randomized controlled trial.
作者信息
Sadeghpour Sonia, Ghasemnejad-Berenji Morteza, Maleki Farzad, Behroozi-Lak Tahereh, Bahadori Robabeh, Ghasemnejad-Berenji Hojat
机构信息
Reproductive Health Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran.
Department of Obstetrics and Gynecology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
出版信息
J Ovarian Res. 2025 Jan 8;18(1):5. doi: 10.1186/s13048-024-01584-0.
BACKGROUND
To investigate the impact of Melatonin on follicular oxidative stress and assisted reproductive technology (ART) outcomes in women with diminished ovarian reserve (DOR).
METHOD
We put 68 women with DOR who were going through ART into a randomized controlled trial. Starting on the fifth day of their menstrual cycle, we gave them either 3 mg of Melatonin or a placebo every day before stimulating their ovaries. We obtained follicular fluid during oocyte retrieval, assessed it for oxidative stress indicators, and documented ART outcomes.
RESULTS
Melatonin administration markedly enhanced the quantity of oocytes retrieved, fertilization rates, and embryo quality. In addition, Melatonin changed markers of oxidative stress, specifically the levels of reduced glutathione (rGSH) and total antioxidant capacity (TAC). The Melatonin group exhibited significantly elevated biochemical pregnancy rates.
CONCLUSION
Melatonin may improve the quality of oocytes and help with reproductive technology in women with low ovarian reserves, possibly by lowering oxidative stress in the follicles.
背景
探讨褪黑素对卵巢储备功能减退（DOR）女性卵泡氧化应激及辅助生殖技术（ART）结局的影响。
方法
我们将68例接受ART治疗的DOR女性纳入一项随机对照试验。从月经周期的第五天开始，在刺激卵巢前，每天给她们服用3毫克褪黑素或安慰剂。在取卵时获取卵泡液，评估其氧化应激指标，并记录ART结局。
结果
服用褪黑素显著提高了获卵数量、受精率和胚胎质量。此外，褪黑素改变了氧化应激标志物，特别是还原型谷胱甘肽（rGSH）和总抗氧化能力（TAC）水平。褪黑素组的生化妊娠率显著提高。
结论
褪黑素可能通过降低卵泡中的氧化应激，改善卵巢储备功能低下女性的卵母细胞质量并有助于生殖技术。
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